前列腺素D2及其代谢物在肿瘤免疫治疗中的潜力:基于动物模型的机制与应用  

Potential of prostaglandin D2 and its metabolites in tumor immunotherapy: mechanisms and applications based on animal models

作　　者：罗洪平 谭邓旭 安庆玲 白冰 张延英[1,3] 师长宏 LUO Hongping;TAN Dengxu;AN Qingling;BAI Bing;ZHANG Yanying;SHI Changhong(Gansu University of Chinese Medicine,Lanzhou 730000,China;Laboratory Animal Center,Air Force Military Medical University,Xi’an 710032,China;Research Center of Traditional Chinese Medicine,Gansu Province,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学,兰州730000 [2]空军军医大学实验动物中心,西安710032 [3]甘肃省中医药研究中心,兰州730000

出　　处：《中国实验动物学报》2025年第3期449-456,共8页Acta Laboratorium Animalis Scientia Sinica

基　　金：国家自然科学基金(32070532,32270566);军队实验动物专项课题(SYDW[2018]08号);陕西省创新能力支撑计划(2022PT-36);甘肃省中医药研究中心开放课题资助(zyzx-2020-zx24,zyzx-2020-zx22)。

摘　　要：前列腺素D2(prostaglandin D2,PGD2)是一种在多种生理和病理过程中具有重要作用的生物活性物质,其主要通过前列腺素D2合酶(prostaglandin D2 synthase,PGDS)发挥生物学功能,且与炎症反应和免疫调节密切相关。近年来基于动物模型的研究发现,PGD2及其合酶PGDS能够通过抑制肿瘤细胞的增殖、诱导细胞凋亡、抑制迁移和侵袭,调节肿瘤免疫微环境,进而影响肿瘤的免疫治疗,展现了其在肿瘤治疗中的潜力。本文综述了PGD2及PGDS的生物学特性,聚焦其在肿瘤动物模型中的免疫治疗作用,探讨PGD2及PGDS通过促进肿瘤微环境中的免疫细胞浸润发挥免疫治疗的效能,期望为肿瘤的治疗提供新的靶点。Prostaglandin D2(PGD2) is a biologically active substance with important roles in a variety of physiological and pathological processes. PGD2 exerts its biological functions mainly through prostaglandin D2 synthase(PGDS), which is closely related to inflammation and immune regulation. Recent studies have found that PGD2 and its synthase, PGDS, are able to directly inhibit tumor cell proliferation, induce apoptosis, suppress migration and invasion, and further regulate the tumor immune microenvironment to affect the immunotherapy of tumors, demonstrating good tumor therapeutic potential. In this paper, we review the biological properties of PGD2 and its synthase, focusing on its role in the immunotherapy of tumor models. We explore the immunotherapeutic efficacy of PGD2 and its synthase, and their roles in promoting immune cell infiltration in the tumor microenvironment, and discuss their potential as new targets for tumor therapy.

关 键 词：前列腺素D2 前列腺素D2合酶 肿瘤 微环境 免疫治疗 

分 类 号：Q95-33[生物学—动物学]