基于内皮细胞衰老探讨从肾论治冠心病的生物学内涵  

Exploration on the Biological Connotation of Treating Coronary Heart Disease from Kidney Based on Endothelial Cell Aging

作　　者：胡伊蕾 蔡磊 马至言 罗晓欣 简维雄 HU Yilei;CAI Lei;MA Zhiyan;LUO Xiaoxin;JIAN Weixiong(College of Chinese Medicine,Hunan University of Chinese Medicine,Changsha 410208,China;National Key Discipline of TCM Diagnositics,Hunan Provincial Key Laboratory,Hunan University of Chinese Medicine,Changsha 410208,China)

机构地区：[1]湖南中医药大学中医学院,湖南长沙410208 [2]湖南中医药大学国家重点学科中医诊断学湖南省重点实验室,湖南长沙410208

出　　处：《中国中医药信息杂志》2025年第4期14-18,共5页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家自然科学基金面上项目(81973753);湖南省自然科学基金(2022JJ30433);湖南省研究生科研创新项目(CX20220781)。

摘　　要：冠心病具有显著年龄相关性,而细胞衰老是机体衰老的基本因素。衰老的内皮细胞可通过氧化应激、线粒体功能障碍等多途径影响冠心病的发展进程。本文围绕内皮细胞衰老促进冠心病相关机制,阐述与中医学“肾”的关联性,肾具有参与生长壮老、精血互化、水液代谢等生理特性,肾精不足可缓生肾浊,肾浊又能继生瘀血、痰浊等邪气侵蚀脉道,与内皮细胞衰老促进斑块发展、加速血栓形成的作用一致。进而从内皮细胞衰老角度探讨从肾论治冠心病的生物学内涵,提出从肾论治冠心病应以补肾泄浊为基本治则,再视其心肾不交、气滞心胸、痰浊阻络、瘀浊阻络等不同证型分别治疗,为中医药治疗冠心病相关生物学研究及临床提供新思路。Coronary heart disease has a significant age correlation,and cell aging is the basic factor of aging of the body.Aging endothelial cells can interfere with the development of coronary heart disease through oxidative stress,mitochondrial dysfunction and other ways.This article focused on the mechanism of endothelial cell aging promoting coronary heart disease,which is related to“kidney”in TCM.Kidney has physiological characteristics such as participating in the growth and aging,the interaction of essence and blood,water and liquid metabolism,etc.Deficiency of kidney essence can slow down the generation of kidney turbidity,which can also be followed by blood stasis,phlegm and other pathogenic factors eroding arteries,which is consistent with the role of endothelial cell aging in promoting plaque development and accelerating thrombosis.The article also discussed the biological connotation of treating coronary heart disease from kidney from the perspective of endothelial cell aging,and put forward that the basic principle of treating coronary heart disease from kidney should be tonifying kidney and expelling turbidity,and then treat it according to different syndromes such as heart-kidney disharmony,qi stagnation in the heart and chest,phlegm obstruction in collaterals and blood stasis obstruction in collaterals,providing new ideas for the biological research and clinical application of TCM in the treatment of coronary heart disease.

关 键 词：细胞衰老 内皮细胞 肾痰 从肾论治 动脉粥样硬化 冠心病 

分 类 号：R259.414[医药卫生—中西医结合]