基于“阴阳”“邪正”理论探讨急性肺损伤细胞焦亡  

Exploration on Cell Pyroptosis in Acute Lung Injury Based on“Yin-yang”Theory and“Pathogenic Factors and Healthy Qi”Theory

作　　者：阮琳峰 骆亚莉 齐晓风[1] 马琳娜 连妮妮 肖孟勇 刘永琦 RUAN Linfeng;LUO Yali;QI Xiaofeng;MA Linna;LIAN Nini;XIAO Mengyong;LIU Yongqi(Provincial Key Laboratory of Molecular Medicine and TCM Prevention and Treatment of Major Diseases in Universities of Gansu Province,Gansu University of Chinese Medicine,Lanzhou 730000,China;Gansu Provincial Key Laboratory of Traditional Chinese Medicine Prevention and Treatment of Chronic Diseases,Gansu University of Chinese Medicine,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学甘肃省高校重大疾病分子医学与中医药防治研究省级重点实验室,甘肃兰州730000 [2]甘肃中医药大学甘肃省中医药防治慢性疾病重点实验室,甘肃兰州730000

出　　处：《中国中医药信息杂志》2025年第4期19-24,共6页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家自然科学基金(82160846);甘肃省中医药科研课题项目(GZKP-2023-32);中西医结合学科“双一流”科研重点项目暨甘肃省中医药防治慢性疾病重点实验室开放课题(2023-09);敦煌医学与转化教育部重点实验室开放课题(DHYX22-12)。

摘　　要：急性肺损伤病理进程中不受控的炎症反应可导致严重后果,细胞焦亡作为细胞程序性炎性坏死,在其中发挥重要推动作用。中医注重机体平衡、阴平阳秘,焦亡过度时机体失衡,在肺则发为肺损伤。本文基于中医学“阴阳”“邪正”理论,从细胞层面讨论细胞焦亡在急性肺损伤发生发展过程中的阴阳变化、消长及对立制约,并阐释中医药防治细胞焦亡可能的作用基础,为中医药干预细胞焦亡防治急性肺损伤提供理论参考。In the pathological process of acute lung injury,uncontrolled inflammatory response will lead to severe consequences,and pyroptosis plays a vital factor in a cell programmed inflammatory necrosis.When the body is imbalanced due to excessive pyroptosis,it can lead to lung injury in the lungs.TCM emphasizes the balance of the body and the balance of yin and yang.Based on the“yin-yang”theory and“pathogenic factors and healthy qi”theory of TCM,this article discussed the yin-yang changes,growth and decline,and opposing constraints of cell pyroptosis in the occurrence and development of acute lung injury at the cellular level,and explained the possible basis of TCM in preventing and treating cell pyroptosis,providing theoretical reference for the intervention of TCM in the prevention and treatment of acute lung injury with cell pyroptosis.

关 键 词：急性肺损伤 细胞焦亡 阴阳 邪正 

分 类 号：R259.63[医药卫生—中西医结合]