参元益气活血胶囊治疗稳定性心绞痛合并室性早搏临床研究  

Clinical Study on Shenyuan Yiqi Huoxue Capsules for the Treatment of Stable Angina Pectoris with Ventricular Premature Beat

作　　者：谢皛[1] 戴梅[1] 张竹华[1] XIE Xiao;DAI Mei;ZHANG Zhuhua(Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing 100010,China)

机构地区：[1]首都医科大学附属北京中医医院,北京100010

出　　处：《中国中医药信息杂志》2025年第4期157-162,共6页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：北京市医院管理局培育计划(PZ2022023)。

摘　　要：目的观察参元益气活血胶囊治疗稳定性心绞痛合并室性早搏的临床疗效。方法选取稳定性心绞痛合并室性早搏患者70例,采用随机数字表法分为对照组和试验组各35例。对照组在西医常规治疗基础上予酒石酸美托洛尔片,25 mg/次,2次/d,口服;试验组在对照组基础上加用参元益气活血胶囊,400 mg/次,3次/d,口服;2组疗程均为3个月。观察2组治疗前后24 h室性早搏次数和疗效、中医证候评分和疗效、心率变异性(HRV)、西雅图心绞痛量表(SAQ)评分,检测2组不良反应情况。结果试验组、对照组分别脱落2、1例。试验组室性期前收缩疗效总有效率为96.97%(32/33),对照组为82.44%(28/34),试验组优于对照组(P<0.05);试验组中医证候总有效率为93.94%(31/33),对照组为73.53%(25/34),试验组优于对照组(P<0.05)。与本组治疗前比较,2组治疗后24 h室性早搏次数均明显减少(P<0.01)。2组治疗后比较,试验组24 h室性早搏次数明显低于对照组(P<0.05)。与本组治疗前比较,2组治疗后HRV各项指标、SAQ分数均显著升高(P<0.01);2组治疗后比较,试验组HRV各项指标、SAQ分数明显高于对照组(P<0.05)。与本组治疗前比较,2组治疗后心悸、胸闷、气短、乏力、自汗、失眠中医证候评分均显著降低(P<0.01)。2组治疗后比较,试验组心悸、胸闷、气短、乏力、自汗、失眠等中医证候评分明显低于对照组(P<0.05)。2组未见明显不良反应。结论参元益气活血胶囊治疗稳定性心绞痛合并室性早搏效果显著,可减少患者24 h室性早搏次数,减轻中医证候,改善HRV、提高SAQ分数,且无明显不良反应。Objective To observe the clinical efficacy of Shenyuan Yiqi Huoxue Capsules for the treatment of stable angina pectoris combined with ventricular premature beat.Methods Totally 70 patients with stable angina pectoris combined with ventricular premature beat were selected,and were divided into control group and experimental group using random number table method,with 35 cases in each group.The control group was given metoprolol tartrate tablets,25 mg/time,twice a day,orally on the basis of conventional Western medicine treatment;the experimental group was treated with Shenyuan Yiqi Huoxue Capsules on the basis of control group treatment,400 mg each time,three times a day.The course of treatment for both groups was three months.The frequency and efficacy of 24 hour ventricular premature beats,TCM syndrome scores and efficacy,heart rate variability(HRV),Seattle Angina Questionnaire(SAQ)score were observed in the two groups before and after treatment.Adverse reactions of both group were monitored.Results The experimental group shed 2 cases,and the control group shed 1 case.The total effective rate of premature ventricular contractions in the experimental group was 96.97%(32/33),while in the control group it was 82.44%(28/34).The experimental group was higher than the control group(P<0.05);the total effective rate of TCM syndrome in the experimental group was 93.94%(31/33),while in the control group it was 73.53%(25/34).The experimental group was higher than the control group(P<0.05).Compared with before treatment,the number of 24 hour ventricular premature beats in both groups decreased significantly after treatment(P<0.01).After treatment,the experimental group had significantly lower 24 hour ventricular premature beats compared to the control group(P<0.05).Compared with before treatment,both groups showed significant increases in HRV indicators and SAQ scores after treatment(P<0.01);after treatment,the HRV indicators and SAQ scores in the experimental group were significantly higher than those in the control group(

关 键 词：室性早搏 参元益气活血胶囊 气虚血瘀证 心率变异性 

分 类 号：R259.41[医药卫生—中西医结合]