瓜子金化学成分和药理作用研究进展及其质量标志物预测分析  

Research Progress in the Chemical Composition and Pharmacological Effects of Polygalae Japonicae Herba and Predictive Analysis on Its Quality Markers

作　　者：刘明英 王春雷 梁晓东[1] 刘轶凡 LIU Mingying;WANG Chunlei;LIANG Xiaodong;LIU Yifan(Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Taian Wang’s Orthopedic Hospital of Shandong Province,Taian 271000,China;Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250014,China)

机构地区：[1]山东中医药大学,山东济南250355 [2]山东省泰安王氏正骨医院,山东泰安271000 [3]山东中医药大学附属医院,山东济南250014

出　　处：《中国中医药信息杂志》2025年第4期180-186,共7页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家自然科学基金青年科学基金(82405291);山东中医药大学青年科研创新团队(2020-54);山东中医药大学教学名师工作室(2022年)。

摘　　要：瓜子金具有祛痰止咳、活血消肿、解毒止痛功效,主要含有三萜皂苷类、黄酮类、酮类、寡糖酯类等多种活性成分,具有抗炎、镇痛、神经保护、抗肿瘤、调节脂质代谢、抗感染性早产等多种药理作用,在治疗神经、代谢等系统疾病方面显示出良好疗效。本文梳理瓜子金的化学成分及药理作用,结合中药质量标志物理念,从植物亲缘学、化学成分特有性、中药功效、中药药性、现代药效用途、化学成分可测性、网络药理学及分子对接技术方面对瓜子金质量标志物进行预测分析,为瓜子金药效物质基础及质量标准研究提供参考。Polygalae Japonicae Herba has the functions of expectorant and relieving cough,promoting blood circulation and detumescence,detoxification and relieving pain.It mainly contains triterpene saponins,flavonoids,xanthones,oligosaccharides and other active components,which has many pharmacological effects,such as anti-inflammatory,analgesic,neuroprotective,anti-tumor,regulation of lipid metabolism,anti-infective preterm birth,etc.,and shows good efficacy in in the treatment of nervous,metabolic and other system diseases.This article reviewed the chemical composition and pharmacological effects of Polygalae Japonicae Herba,combining the concept of quality markers of Chinese materia medica,predicted and analyzed the quality markers of Polygalae Japonicae Herba based on plant phylogenetics,uniqueness of chemical components,efficacy of Chinese materia medica,pharmacological properties of Chinese materia medica,new pharmacological effects,detectability of chemical components,network pharmacology and molecular docking technology,in order to provide reference for the study on the material basis of the medicinal effects and quality standards of Polygalae Japonicae Herba.

关 键 词：瓜子金 化学成分 瓜子金皂苷己 药理作用 质量标志物 预测分析 

分 类 号：R285[医药卫生—中药学]