针刺干预抑郁症脑网络机制研究进展  

Research Progress in Brain Network Mechanism of Acupuncture Intervention in Depression

作　　者：刘斗 张惠春 申亚男 李蜀娟 肖敏 李芃菲 马重兵 LIU Dou;ZHANG Huichun;SHEN Yanan;LI Shujuan;XIAO Min;LI Pengfei;MA Chongbing(School of Acupuncture and Tuina,Gansu University of Chinese Medicine,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学针灸推拿学院,甘肃兰州730000

出　　处：《中国中医药信息杂志》2025年第4期187-192,共6页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家自然科学基金(82360974);甘肃省高校青年博士支持项目(2023QB-088);甘肃中医药大学2020-2021年引进人才科研启动基金项目(2023YJRC-01);甘肃省针灸推拿临床医学中心开放基金项目(ZJKF2204)。

摘　　要：针刺治疗抑郁症安全且有效,其机制尚不完全明确。本文从脑网络角度梳理针刺干预抑郁症机制研究。抑郁症患者大脑结构网络和功能网络(默认网络、认知控制网络、突显网络和情绪网络等)存在异常改变,针刺可通过提高脑白质弥散各向异性值,修复关键脑区脑白质纤维束微观结构;调节功能网络整体或部分网络激活程度,改善功能网络内部及网络间功能连接,调节功能网络全局传递效率和连接模式,恢复脑网络交互平衡,调控功能网络整合异常,改善情绪调节能力、认知功能,从而改善抑郁症患者临床症状,达到抗抑郁的目的,可为针刺干预抑郁症脑网络机制研究提供参考。Acupuncture is considered both safe and effective for treating depression;however,its underlying mechanism remains incompletely understood.This article reviewed the mechanisms of acupuncture in depression from the perspective of brain network dynamics.It has been found abnormal alterations in the structural and functional brain networks,including the default mode network,cognitive control network,salience network and affective network in individuals with depression.Acupuncture has been shown to enhance the diffusion anisotropy value of white matter and repair the microstructure of white matter fiber bundles in key brain regions.It can also modulate the activation the functional brain networks,either globally or in specific network segments,improve functional connectivity within and between functional networks,regulate global transmission efficiency and connectivity patterns of functional networks,restore brain network interaction balance,regulate abnormal integration of functional networks,and improve emotional regulation ability and cognitive function,in order to alleviate the clinical symptoms of depression and serve as an effective antidepressant therapy,which can provide reference for the study of acupuncture intervention in the brain network mechanism of depression.

关 键 词：针刺 抑郁症 脑网络 结构网络 功能网络 综述 

分 类 号：R245[医药卫生—针灸推拿学]