中药复方治疗帕金森病实验研究进展  

Experimental Research Progress of TCM Compounds in the Treatment of Parkinson Disease

作　　者：吕子微 梁建庆 王行玲 孙光洁 LYU Ziwei;LIANG Jianqing;WANG Xingling;SUN Guangjie(Basic Medical College,Gansu University of Chinese Medicine,Lanzhou 730000,China;Key Laboratory of Dunhuang Medicine and Translational Education Ministry,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学基础医学院,甘肃兰州730000 [2]敦煌医学与转化教育部重点实验室,甘肃兰州730000

出　　处：《中国中医药信息杂志》2025年第4期193-196,F0003,共5页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家自然科学基金(82160929);甘肃省科技厅省级科技计划自然科学基金(自筹经费)项目(21JR11RA143、24JRRA1028);敦煌医学与转化教育部重点实验室开放课题(DHYX22-06);中医学一级学科“岐黄英才”导师专项基金硕导项目(ZYXKSD-202211)。

摘　　要：帕金森病发病率随着人口老龄化加重逐年升高。中药复方治疗帕金森病具有多成分、多靶点、多通路特点,与西药联合治疗可起到协同增效、减轻药物不良反应作用。本文围绕中药复方治疗帕金森病机制,梳理近年相关实验研究,中药复方可能通过调节氧化应激、线粒体功能障碍、神经递质、神经炎症、异常蛋白聚集、细胞凋亡、干细胞移植、神经营养因子、第二信使等机制发挥治疗帕金森病作用,以期为临床治疗帕金森病提供依据。Parkinson disease is a progressive neurodegenerative disease whose incidence increases year by year as the population ages.TCM compounds for the treatment of Parkinson disease has the characteristics of multiple components,targets,and pathways.Combined treatment with Western medicine can achieve synergistic effects and reduce adverse drug reactions.This article focused on the mechanism of TCM compounds for the treatment of Parkinson disease,reviewed relevant experimental studies in recent years.TCM compounds may exert therapeutic effects on Parkinson disease by regulating oxidative stress,mitochondrial dysfunction,neurotransmitters,neuroinflammation,abnormal protein aggregation,cell apoptosis,stem cell transplantation,neurotrophic factors,second messengers,and other mechanisms,in order to provide basis for clinical treatment of Parkinson disease.

关 键 词：帕金森病 中药复方 实验研究 作用机制 综述 

分 类 号：R277.71[医药卫生—中医学]