基于“脑肠轴”理论的中医药对功能性便秘机体内脑肠肽含量变化影响研究进展  

Research Progress on Effect of Changes in Brain Gut Peptide Content in Functional Constipation Patients Treated with Traditional Chinese Medicine Based on the“Brain Gut Axis”Theory

作　　者：黄显达 姜洪宇 隋楠[2] HUANG Xianda;JIANG Hongyu;SUI Nan(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning,China;The Third Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110003,Liaoning,China)

机构地区：[1]辽宁中医药大学,辽宁沈阳110847 [2]辽宁中医药大学附属第三医院,辽宁沈阳110003

出　　处：《辽宁中医药大学学报》2025年第5期58-63,共6页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：国家自然科学基金(82174370)。

摘　　要：目前,功能性便秘(functional constipation,FC)在人群中的发病率较高,尤其在老年群体中。这严重影响了老年人的生活质量。因此,对于FC的基础研究与临床治疗尤为重要。研究发现,机体内存在大脑与胃肠道双重分布的肽类激素——脑肠肽。FC患者机体内存在着脑肠肽含量的变化。机体内与FC有关的脑肠肽主要有血管活性肽、胃动素、P物质等。这些脑肠肽含量的变化通过脑肠轴影响着胃肠的生理功能,与FC的发病密切相关。目前关于中医药对FC机体内脑肠肽含量变化影响的研究为医学研究的热点。该文收集近3年中药及复方、针灸调控FC机体内脑肠肽含量变化相关文献,期望为医家们研究FC提供帮助。中医方面,脑与脾胃、大肠、小肠之间通过气、血、津液、精、髓、经络相互联系,与西医学脑肠轴相似;该文从中西医不同角度论述二者之间的联系。此外,“气”与脑肠肽从概念、生成、功能、运行等方面关系密切,为从调气的角度调控体内脑肠肽的水平提供思路。Currently,functional constipation(FC)has a high incidence in the population,especially in the elderly.This seriously affects the quality of life of older people.Therefore,the basic research and clinical treatment of FC is particularly important.Studies have found that there are peptide hormones in the body,which are distributed in the brain and gastrointestinal tract.There are changes of brain and intestinal peptide content in FC body.The main brain and intestinal peptides related to FC in the body are vasoactive peptide,motilin,substance P and so on.These changes of brain-gut peptide content affect the physiological function of the gastrointestinal tract through the brain-gut axis,and are closely related to the pathogenesis of FC.At present,the study on the change of brain and intestinal peptide content in FC body by traditional Chinese medicine is a hot topic in medical research.In this paper,we collected the relevant literature on the regulation of brain and intestinal peptide content in FC body by TCM and acupuncture in the past 3 years,hoping to provide help for doctors to study FC.In traditional Chinese medicine,the brain,spleen and stomach,large intestine and small intestine are connected with each other through Qi,blood,body fluid,essence,pulp and meridians,which is similar to the axis of brain and intestine in Western medicine.This paper tries to discuss the relationship between Chinese and Western medicine from different angles.In addition,“Qi”is closely related to brain-gut peptide in terms of concept,generation,function and operation.It provides a way to regulate the level of brain and intestinal peptide in vivo from the perspective of regulating Qi.

关 键 词：功能性便秘 脑肠肽 脑肠轴 气 中医药治疗 

分 类 号：R256.35[医药卫生—中医内科学]