仙灵骨葆胶囊临床应用及药理作用机制研究进展  

Research Progress on Clinical Application and Pharmacological Mechanism of Xianling Gubao Capsule(仙灵骨葆胶囊)

作　　者：雷阳 卜献忠 张向北 王凯[2] 孟东方[1] 李慧英[1] LEI Yang;BU Xianzhong;ZHANG Xiangbei;WANG Kai;MENG Dongfang;LI Huiying(The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,Henan,China;Henan University of Chinese Medicine,Zhengzhou 450000,Henan,China)

机构地区：[1]河南中医药大学第一附属医院,河南郑州450000 [2]河南中医药大学,河南郑州450000

出　　处：《辽宁中医药大学学报》2025年第5期119-125,共7页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：国家自然科学基金青年科学基金项目(82405439);河南省中医药科学研究专项(2021JDZY009,2022JDZX123,2023ZY2029)。

摘　　要：仙灵骨葆胶囊是骨伤科常用药物,对骨关节炎、骨质疏松、骨折、股骨头坏死、强直性脊柱炎、腰椎间盘突出等常见疾病均有显著疗效。通过梳理国内外文献,补充前人研究的不足之处,发现:仙灵骨葆胶囊联合氨基葡萄糖治疗骨关节炎效果最好,疼痛症状明显者可合用非甾体类抗炎药;对于骨质疏松性椎体压缩性骨折、股骨颈骨折等老年性骨折术后持续应用仙灵骨葆胶囊可减少骨折再发风险;对于股骨头坏死行保髋治疗者,无论是单纯药物还是需联合减压植骨,仙灵骨葆胶囊均可作为优先选择。仙灵骨葆胶囊主要调控相关信号通路蛋白表达,通过抗炎、调节骨代谢、促血管新生、调节雌激素水平、影响肠道微生物群等方面发挥治疗作用。仙灵骨葆胶囊所致不良反应主要是肝损伤,药物组成中补骨脂是主要毒性成分,机体炎症环境和药物剂型是不良反应发生的高危因素。Xianling Gubao Capsule(仙灵骨葆胶囊)is a commonly used drug in orthopedics and trauma department.It has significant effects on common diseases such as osteoarthritis,osteoporosis,fracture,femur head necrosis,ankylosing spondylitis,lumbar disc herniation and so on.By combing domestic and foreign literature to supplement the shortcomings of previous studies,it was found that Xianling Gubao Capsule combined with glucosamine has the best effect in the treatment of osteoarthritis,and non-steroidal anti-inflammatory drugs can be used in patients with obvious pain symptoms.For senile fractures such as osteoporotic vertebral compression fracture and femoral neck fracture,continuous application of Xianling Gubao Capsule after operation can reduce the risk of recurrence of fracture.Xianling Gubao Capsule can be used as a preferred choice for hip preservation treatment for femoral head necrosis,whether with drugs alone or with combined decompression and bone grafting.Xianling Gubao Capsule mainly regulates the expression of related signaling pathway proteins,and plays a therapeutic role by anti-inflammatory,regulating bone metabolism,promoting angiogenesis,regulating estrogen levels,and affecting intestinal microbiota.The main adverse reactions caused by Xianling Gubao Capsule were liver injury,psoralen was the main toxic component in the drug composition,and the inflammatory environment and drug dosage form were the high risk factors for the occurrence of adverse reactions.

关 键 词：仙灵骨葆胶囊 临床应用 药理作用 作用机制 不良反应 

分 类 号：R289.5[医药卫生—方剂学]