机构地区:[1]南京中医药大学附属南京市中西医结合医院,江苏南京210014 [2]南京医科大学附属南京医院,江苏南京210006
出 处:《辽宁中医药大学学报》2025年第5期176-180,共5页Journal of Liaoning University of Traditional Chinese Medicine
基 金:国家自然科学基金面上项目(82174125);江苏省第三批中医药领军人才项目(SLJ0308);江苏省中西医结合学会青年科技人才托举工程项目(JSZXTJ-2024-B03);南京市卫生科技发展专项资金项目(ZKΧ21057,YKK21193)。
摘 要:目的评价柴胡加龙骨牡蛎汤联合奥美拉唑治疗胆火上逆型非糜烂性反流病(non-erosive reflux disease,NERD)的临床疗效。方法采用随机数字表法将64例NERD患者分成对照组和试验组,每组32例。对照组予以口服奥美拉唑肠溶胶囊治疗,试验组在此基础上联合服用柴胡加龙骨牡蛎汤治疗,疗程8周。观察两组患者反流性疾病问卷(RDQ)积分、中医症状总积分、中医证候总有效率、胃食管反流病健康相关生存质量量表(GERDHRQL)积分以及躯体化症状自评量表(SSS)积分的变化情况,评估用药安全性。结果治疗后,试验组RDQ积分、中医症状总积分均显著低于对照组,差异具有统计学意义(P<0.01);试验组中医证候总有效率明显高于对照组,差异具有统计学意义(P<0.01);试验组GERD-HRQL积分、SSS积分均显著低于对照组,差异具有统计学意义(P<0.01)。两组治疗期间均未发生不良反应事件。结论柴胡加龙骨牡蛎汤联合奥美拉唑治疗胆火上逆型NERD安全有效,在控制酸反流、改善中医症状、提高患者生活质量、减轻躯体化症状等方面均优于单纯奥美拉唑治疗,中西医结合治疗NERD相比西医治疗更具优势。Objective To evaluate the clinical efficacy on Chaihu and Longgu Muli Decoction(柴胡加龙骨牡蛎汤)combined with omeprazole in treatment of nonerosive reflux disease(NERD)with flaming-up of gallbladder-fire type.Methods 64 NERD patients were divided into control and trial groups,with 32 NERD patients in each group.The control group was treated with omeprazole enteric capsules,and the test group was treated with omeprazole enteric capsules and Chaihu and Longgu Muli Decoction.The course in both groups was 8 weeks.The changes of reflux disease questionnaire(RDQ)points,total points of traditional Chinese medicine symptoms,total response rate of traditional Chinese medicine syndrome,health related quality of life scale for gastroesophageal reflux disease(GERD-HRQL)points and somatic self-rating scale(SSS)points were observed,and the safety of medication was evaluated.Results After treatment,the RDQ score and total score of traditional Chinese medicine symptoms were significantly lower than those of the control group,statistically different(P<0.01).The total response rate of traditional Chinese medicine syndrome was significantly higher than that of the control group,and the difference was statistically significant(P<0.01);the GERD-HRQL score and SSS score were significantly lower than those of the control group(P<0.01).There were no adverse events during the treatment period.Conclusion The clinical efficacy and safety evaluation on Chaihu and Longgu Muli Decoction combined with omeprazole in treatment of nonerosive reflux disease with flaming-up of gallbladder-fire type were confirmed.In addition,it is better than omeprazole alone in controlling acid reflux,improving traditional Chinese medicine symptoms,improving the quality of life of patients,and reducing somatization symptoms.It can be seen that the combination of traditional Chinese and western medicine has more advantages in treating NERD compared with western medicine.
关 键 词:柴胡加龙骨牡蛎汤 非糜烂性反流病 临床疗效 生活质量 情绪障碍
分 类 号:R256.3[医药卫生—中医内科学]
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