针灸对非酒精性脂肪性肝病的治疗机制及相关潜在治疗策略研究进展  

Research Progress of Mechanism of Acupuncture and Related Potential Treatment Strategies for Non-alcoholic Fatty Liver Disease

作　　者：李诗琪 朱梅 熊哲锟 王彩鸾 郑财福 甘礼明 LI Shiqi;ZHU Mei;XIONG Zhekun;WANG Cailuan;ZHENG Caifu;GAN Liming(Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Chinese Medicine,Zhongshan 528400,Guangdong,China;Guangzhou University of Chinese Medicine,Guangzhou 510400,Guangdong,China)

机构地区：[1]广州中医药大学附属中山中医院,广东中山528400 [2]广州中医药大学,广东广州510400

出　　处：《辽宁中医药大学学报》2025年第5期191-195,共5页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：广东省中医药局科研项目(20212251)。

摘　　要：非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)是全球最常见的慢性肝病,其发病率呈逐渐上升趋势和低龄化趋势。临床病谱从单纯性脂肪变性和非酒精性脂肪性肝炎到纤维化、肝硬化,甚至进展为肝细胞癌。针灸是一种经长期医疗实践验证的成熟的中医治疗方法,已被广泛应用于预防和治疗各种疾病。以往的研究对针灸治疗NAFLD的有效性和相关机制提供了越来越多的证据。该文回顾了针灸治疗NAFLD相关机制的最新进展,并讨论了针灸治疗NAFLD的相关机制和途径,包括改善胰岛素抵抗、改善NAFLD的脂质代谢紊乱、抑制炎症反应、调节NAFLD患者肠道菌群失调和拮抗NAFLD氧化应激损伤。另外,该文还描述了针灸治疗NAFLD的相关潜在治疗策略,包括针灸联合艾灸、八段锦、中药汤剂、耳穴压贴、刮痧、甘草酸二铵和益生菌等疗法。综上所述,临床上使用针灸以及针灸联合其他疗法治疗NAFLD可能是一种有前途的策略。Non-alcoholic fatty liver disease(NAFLD)is the most common chronic liver disease in the world,and its incidence is gradually increasing and the age is younger.The clinical spectrum ranges from simple steatosis and non-alcoholic steatohepatitis to fibrosis,cirrhosis and even hepatocellular carcinoma.Acupuncture and moxibustion is a mature TCM treatment method verified by long-term medical practice and has been widely used to prevent and treat various diseases.Previous studies have provided increasing evidence on the effectiveness and mechanisms of acupuncture in the treatment of NAFLD.Here,it reviewed the latest progress of acupuncture and moxibustion in the treatment of NAFLD,and discussed the relevant mechanisms and pathways of acupuncture and moxibustion in the treatment of NAFLD,including improving insulin resistance,improving lipid metabolism disorders in NAFLD,inhibiting inflammatory response,regulating intestinal flora disorders in NAFLD patients,and antagonizing oxidative stress damage in NAFLD.In addition,it described potential strategies related to acupuncture and moxibustion for NAFLD,including acupuncture combined with moxibustion,Baduanjin,Chinese herbal decoction,auricular point pressure paste,Guasha,diammonium glycyrrhizinate and probiotics.In summary,the clinical use of acupuncture and moxibustion in combination with other therapies for NAFLD may be a promising strategy.

关 键 词：针灸 非酒精性脂肪性肝病 治疗机制 联合治疗 

分 类 号：R256.4[医药卫生—中医内科学]