基于络病理论探析虫类药在脑小血管病中的应用  

Exploration of the Application of Insect Drugs in Cerebral Small Vessel Disease Based on Collateral Disease Theory

作　　者：余婷 刘扬 贺凡 马岱朝 李庆 张慧 YU Ting;LIU Yang;HE Fan;MA Daichao;LI Qing;ZHANG Hui(Shaanxi University of Chinese Medicine,Xianyang 712046,Shaanxi,China;Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang 712000,Shaanxi,China)

机构地区：[1]陕西中医药大学,陕西咸阳712046 [2]陕西中医药大学附属医院,陕西咸阳712000

出　　处：《辽宁中医药大学学报》2025年第5期200-204,共5页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：国家中医药管理局中医药科学技术研究专项课题(GYZ-KJS-2021-001);陕西省科学技术厅创新能力支撑计划项目(2017KCT-26);陕西省自然科学基础研究计划项目(2023-JC-YB-721,2023-JC-QN-0957)。

摘　　要：脑小血管病是神经内科领域的一种常见且隐蔽的脑血管疾病,其发病机制复杂,且至今尚未找到有效的治疗药物。尽管现代医学技术在一定程度上能够控制病情的进展,但药物带来的不良反应也令人担忧,这给患者、家庭乃至整个社会带来了沉重的负担。近年来,中医络病理论在脑小血管病的临床治疗中受到了广泛关注和应用。络病理论作为中医学的重要组成部分,为脑小血管病的治疗提供了新的思路。虫类药物因其独特的药理作用,在脑小血管病的治疗中展现出了显著的效果。虫类药物有深入络脉、搜剔病邪之特性,具备活血化瘀、通络止痛及补益培元等多重功效,使得其在脑小血管病的治疗中能够发挥独特的疗效。现代药理研究已深入解析虫类药物在治疗脑小血管病时的多元化机制,其不仅能有效改善微循环,促进血管新生,还具备抗凝血与抗血栓、抗炎、抗氧化、调节免疫以及神经保护与修复等功效。该文旨在基于络病理论,深入探讨虫类药物在脑小血管病治疗中的应用,以期为拓宽脑小血管病的中医治疗思路提供有益的参考。Cerebral small vessel disease is a common and insidious cerebrovascular disease in the field of neurology,whose pathogenesis is quite complex and for which no effective therapeutic drugs have yet been found.Although modern medical technology can control the progression of the disease to a certain extent,the side effects brought by drugs are also worrying,which brings a heavy burden to patients,families and even the whole society.In recent years,collateral disease theory has received widespread attention and application in the clinical treatment of cerebral small vessel disease.As an important part of Chinese medicine,collateral disease theory provides new ideas for the treatment of cerebral small vessel disease.Insect drugs have shown remarkable effects in the treatment of cerebral small vessel disease due to their unique pharmacological effects.Insect drugs have the characteristics of penetrating deep into collaterals and searching for diseases and evils,and have the multiple effects of activating blood circulation and removing blood stasis,clearing collaterals and relieving pain,and tonifying and cultivating the vital energy,which enable them to play a unique therapeutic effect in the treatment of cerebral small-vessel disease.Modern pharmacological studies have deeply analyzed the diversified mechanisms of insect drugs in the treatment of cerebral small vessel disease,which can not only effectively improve microcirculation and promote vascular neovascularization,but also have the effects of anticoagulation and antithrombosis,anti-inflammation,antioxidant,immunity regulation,and neuroprotection and repair,and so on.The purpose of this paper is to discuss the application of insect drugs in the treatment of cerebral small vessel disease based on the collateral disease theory,with a view to providing useful references to broaden the ideas of traditional Chinese medicine treatment of cerebral small vessel disease.

关 键 词：络病理论 虫类药物 脑小血管病 中医药 

分 类 号：R255.2[医药卫生—中医内科学] R255.3[医药卫生—中医学]