氟比洛芬酯对术后导尿管相关性膀胱刺激征的影响:一项随机对照双盲试验  

Effect of flurbiprofen axetil on postoperative catheter-related bladder discomfort:a randomized,controlled,double-blind trial

作　　者：刘志丹 宋波 李丽萍 郭尹浩 何红霞 徐岁寒 张永洪 李军 LIU Zhidan;SONG Bo;LI Liping;GUO Yinhao;HE Hongxia;XU Suihan;ZHANG Yonghong;LI Jun(Department of Anesthesiology,School of Clinical Medieine,Southwest Medical University,Luzhou 646000,Sichuan Province,China;Department of Anesthesiology,Mianyang Central Hospital,School of Medicine,University of Electronic Science and Technology of China,Mianyang 621000,Sichuan Province,China)

机构地区：[1]西南医科大学临床医学院麻醉科,四川泸州646000 [2]电子科技大学医学院附属绵阳医院·绵阳市中心医院麻醉科,四川绵阳621000

出　　处：《药物流行病学杂志》2025年第4期373-379,共7页Chinese Journal of Pharmacoepidemiology

基　　金：绵阳市卫生健康委医学科研课题(202165)。

摘　　要：目的探讨静脉注射氟比洛芬酯对前列腺电切术(TURP)后导尿管相关膀胱刺激征(CRBD)发生率及严重程度的影响。方法选择择期全麻下行经尿道TURP术的老年患者,并随机分为氟比洛芬酯组(F组)和对照组(C组)。手术结束前10 min,F组静脉注射氟比洛芬酯50 mg,C组给予等量0.9%氯化钠注射液。研究主要结局指标为进入复苏室即刻(T0)的中重度CRBD发生率;次要指标包括进入复苏室后1 h(T1)、2 h(T2)、6 h(T3)的CRBD发生率及严重程度、术后24 h内舒芬太尼使用量、术后各时点疼痛数字评分(NRS)、术后24 h氟比洛芬酯和镇痛药相关不良反应以及患者满意度。结果最终纳入90例患者,F组和C组各45例。T0时F组中重度CRBD发生率明显低于C组(8.9%vs.33.3%,P=0.004)。T1、T2、T3时F组CRBD发生率均低于C组(P<0.05);且T3时轻度CRBD发生率低于C组(P<0.05),T1、T2时中重度CRBD发生率低于C组(P<0.05)。术后24 h F组舒芬太尼使用量明显低于C组(P=0.001);T0、T1、T2、T3时F组NRS评分均均低于C组(P<0.05);F组术后患者满意度评分高于C组(P=0.001);2组术后麻醉复苏时间、24 h不良反应发生率差异均无统计学意义(P>0.05)。结论静脉注射氟比洛芬酯能安全有效地减少TURP术后CRBD发生率,减轻其严重程度,可明显缓解疼痛,减少舒芬太尼使用量,具有较高的临床应用价值。Objective To investigate the effect of intravenous flurbiprofen axetil on the incidence and severity of catheter-related bladder discomfort(CRBD)after transurethral resection of the prostate(TURP).Methods The elderly patients undergoing TURP under general anesthesia were enrolled,and randomly divided into two groups:flurbiprofen axetil group(group F)and control group(group C).Ten minutes before the end of surgery,group F was given 50 mg of flurbiprofen axetil intravenously,group C was given an equal amount of 0.9%sodium chloride injection.The primary outcome indicator was the incidence of moderate to severe CRBD immediately after entering the resuscitation room(T0).Secondary indicators included the incidence and severity of CRBD at 1 h(T1),2 h(T2),and 6 h(T3)after entering the resuscitation room,the amount of sufentanil used within 24 hours after surgery,postoperative NRS score,flurbiprofen axetil-related and analgesic adverse reactions 24 hours after surgery,and patient satisfaction.Results A total of 90 patients were included and each group was 45 patients.The incidence of moderate to severe CRBD at T0 was significantly lower in group F than that in group C(8.9%vs.33.3%,P=0.004).The incidence of CRBD in T1,T2,and T3 was lower in group F than in group C(P<0.05).The incidence of mild CRBD at T3 in group F was lower than that in group C(P<0.05).The incidence of moderate to severe CRBD at T1 and T2 in groups F was lower than that in group C(P<0.05).The amount of sufentanil used in group F at 24 hours after surgery was significantly lower than that in group C(P=0.001).The pain scores in group F at T0,T1,T2,and T3 were lower than those in group C(P<0.05);The postoperative patient satisfaction score in group F was higher than that in group C(P=0.001).However,there were no significant differences between the two groups in postoperative anesthesia resuscitation time and 24-hour adverse reactions incidence(P>0.05).Conclusion Intravenous flurbiprofen axetil can safely and effectively reduce the incidence and severity of C

关 键 词：氟比洛芬酯 前列腺电切术 导尿管相关性膀胱刺激征 随机对照试验 

分 类 号：R971.12[医药卫生—药品]