维生素D及其信号通路在疾病中的作用研究进展  

Research progress on the role of vitamin D and its signaling pathway in disease development

作　　者：张小美 叶慧[2] 杨芳[3] 闵锐 童叶青[3] ZHANG Xiaomei;YE Hui;YANG Fang;MIN Rui;TONG Yeqing(School of Public Health,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430011,China;Xiantao Center for Disease Control and Prevention,Xiantao 433099,Hubei Province,China;Hubei Provincial Center for Disease Control and Prevention,Wuhan 430079,China)

机构地区：[1]华中科技大学同济医学院公共卫生学院,武汉430011 [2]仙桃市疾病预防控制中心,湖北仙桃433099 [3]湖北省疾病预防控制中心,武汉430079

出　　处：《药物流行病学杂志》2025年第4期456-466,共11页Chinese Journal of Pharmacoepidemiology

基　　金：国家自然科学基金重大研究计划项目(92169117);湖北省青年拔尖人才项目(20211018)。

摘　　要：维生素D是一种脂溶性维生素,主要通过皮肤暴露于紫外线B照射下合成,也可以通过饮食摄入。其生物学作用不仅限于钙和磷的代谢调控,还涉及免疫调节、抗炎、抗肿瘤等多种生理功能。近年来,随着研究的深入,维生素D信号通路在各种疾病中的作用逐渐被揭示,其调节机制复杂且多样。本文系统梳理了维生素D信号通路的分子机制,包括维生素D的两步羟化活化过程、维生素D受体(VDR)介导的基因转录调控、维生素D结合蛋白与代谢酶(1α-羟化酶/24-羟化酶)的动态平衡调控,以及与核因子κB、Wnt、Hedgehog等信号通路的交互作用。重点阐述了维生素D通过抗炎、免疫调节、细胞周期调控等机制在炎症性肠病、糖尿病及其并发症、肥胖、心血管疾病、结直肠癌、乳腺癌等多系统疾病中的作用,构建维生素D信号通路的系统认知框架,为靶向VDR的精准治疗策略提供理论依据。Vitamin D is a fat-soluble vitamin primarily synthesized through skin exposure to ultraviolet B irradiation and dietary intake.Its biological effects are not limited to the regulation of calcium and phosphorus metabolism but also involve a variety of physiological functions such as immune modulation,anti-inflammation,and anti-tumor.In recent years,as research deepens,the role of the vitamin D signaling pathway in various diseases has been gradually revealed,and its regulatory mechanisms are complex and diverse.This paper systematically reviews the molecular mechanisms underlying the vitamin D signaling pathway,including the two-step hydroxylation activation process of vitamin D,the regulation of gene transcription mediated by the vitamin D receptor(VDR),the homeostatic regulation involving vitamin D-binding protein and metabolic enzymes such as 1α-hydroxylase and 24-hydroxylase,and interactions with other signaling pathways,including NF-κB,Wnt,and Hedgehog.This study highlights the role of vitamin D in various multi-system diseases such as inflammatory bowel disease,diabetes and its complications,obesity,cardiovascular disease,colorectal cancer,breast cancer,among others.The systematic cognitive framework for understanding the vitamin D signaling pathway was conducted,providing a theoretical basis for precision treatment strategies targeting VDR.

关 键 词：维生素D 信号通路 疾病发生 

分 类 号：R977.24[医药卫生—药品]