疑似肌苷注射液致类白血病反应1例分析  

Analysis of one case of suspected leukemic reaction caused by inosine injection

作　　者：黄怡新 朱芹汶 吴依繁 刘鑫炎 HUANG Yixin;ZHU Qinwen;WU Yifan;LIU Xinyan(Department of Pharmacy,Suzhou Kowloon Hospital,Shanghai JiaoTong University School of Medicine,Suzhou 215028,Jiangsu Province,China)

机构地区：[1]上海交通大学医学院苏州九龙医院药学部,江苏苏州215028

出　　处：《药物流行病学杂志》2025年第4期480-484,共5页Chinese Journal of Pharmacoepidemiology

摘　　要：1例34岁女性车祸多发伤患者入院应用肌苷注射液,11 d后出现以“白细胞计数异常升高”为主的类白血病反应,白细胞计数最高可达38.26×10^(9)·L^(-1),考虑为肌苷注射液引起,停用该药后白细胞计数逐渐降低至15.84×10^(9)·L^(-1)。采用Naranjo's评估量表对肌苷注射液与不良反应的关联性进行评价,评分为6分,结果为“很可能有关”。本文报道的案例属于肌苷注射液导致的新的不良反应,提示肌苷注射液作为辅助用药,用药安全应受到重视,若出现白细胞计数异常升高的情况,需警惕“类白血病反应”可能,必要时及时停药。A 34-year-old female patient with multiple injuries in a car accident was admitted to hospital and received inosine injection.After 11 days,leukemioid reaction mainly characterized by"abnormal increase in white blood cell count"occurred,and the white blood cell count reached up to 38.26×10^(9)·L^(-1).Considering that inosine injection was the cause,the white blood cell count gradually decreased to 15.84×10^(9)·L^(-1)after the drug was stopped.Naranjo's assessment scale was used to evaluate the association of adverse reactions,with a score of 6,and the result was"very likely to be relevant".The cases reported in this paper belong to new adverse reactions caused by inosine injection,suggesting that inosine injection as an adjunct should pay attention to drug safety.If there is an abnormal increase in white blood cell count,it is necessary to be alert to the possibility of"leukemioid reaction"and stop the drug in time if necessary.

关 键 词：肌苷注射液 类白血病反应 药品不良反应 

分 类 号：R977[医药卫生—药品]