薯蓣皂苷的抗炎作用机制研究进展  

Research progress on anti-inflammatory action mechanism of dioscin

作　　者：赖敏 邓汝彬 邓嘉磊 廖海荣 杨树龙 LAI Min;DENG Rubin;DENG Jialei;LIAO Hairong;YANG Shulong(Key Research Laboratory of Chronic Disease,Fuzhou Medical College,Nanchang University,Jiangxi Province,Fuzhou344100,China;Department of Physiology,Fuzhou Medical College,Nanchang University,Jiangxi Province,Fuzhou344100,China;Technology Innovation Center of Chronic Disease Research in Fuzhou City,Jiangxi Province,Fuzhou344100,China)

机构地区：[1]南昌大学抚州医学院慢性病研究重点实验室,江西抚州344100 [2]南昌大学抚州医学院生理学教研室,江西抚州344100 [3]江西省抚州市慢性病研究技术创新中心,江西抚州344100

出　　处：《中国医药导报》2025年第9期46-50,共5页China Medical Herald

基　　金：国家自然科学基金资助项目(82060661);江西省高等学校教学改革研究课题(JXJG-22-130-1);江西省抚州市社会发展指导性科技计划项目(抚科社字〔2022〕9号)。

摘　　要：炎症是机体免疫系统对各种损伤因子刺激所做出的一系列反应,与多种疾病的发生和发展有密切关系。薯蓣皂苷是一种天然的皂苷化合物,具有抗炎、抗肿瘤等多种药理作用。近年来,薯蓣皂苷的抗炎作用备受关注,相关机制研究取得较大进展,但缺乏系统整理。本文通过查阅和分析大量相关文献,对其进行归纳和整理,发现薯蓣皂苷抗炎机制具有多样性,主要通过调节TRL、NF-κB、NLRP3炎症小体、氧化应激、巨噬细胞表型变化等信号通路发挥作用。因此,本文按作用途径综述薯蓣皂苷抗炎作用机制的研究进展,为研究薯蓣皂苷相关结构的新型抗炎药物提供思路与启发。Inflammation is a series of reactions of the body’s immune system to various damaging factors,which are closely related to the occurrence and development of various diseases.Dioscin is a natural saponin compound,has various pharmacological effects such as anti-inflammatory and anti-tumor effects.In recent years,anti-inflammatory effects of dioscin have attracted much attention,significant progress has been made in the study of related mechanisms,but there is a lack of systematic organization.This article summarizes and organizes a large number of relevant literature through review and analysis,finds that anti-inflammatory mechanism of dioscin is diverse,mainly through regulating signaling pathways such as TRL,NF-κB,NLRP3 inflammasome,oxidative stress,and macrophage phenotype changes.Therefore,this article reviews research progress on anti-inflammatory mechanism of dioscin by its action pathway,providing ideas and inspiration for the study of new anti-inflammatory drugs related to the structure of dioscin.

关 键 词：薯蓣皂苷 抗炎作用 炎症 

分 类 号：R285[医药卫生—中药学]