基于p38MAPK信号通路探讨中药防治冠心病的研究进展  

Chinese Medicine Prevention and Treatment of Coronary Heart Disease Based on p38MAPK Signaling Pathway:A Review

作　　者：胡伊蕾 罗晓欣 马至言 杨欣雨 白思杨 简维雄 HU Yilei;LUO Xiaoxin;MA Zhiyan;YANG Xinyu;BAI Siyang;JIAN Weixiong(College of Traditional Chinese Medicine,Hunan University of Chinese Medicine,Changsha 410208,China;Hunan Provincial Key Laboratory of National Key Discipline Diagnostics of Traditional Chinese Medicine,Hunan University of Chinese Medicine,Changsha 410208,China)

机构地区：[1]湖南中医药大学中医学院,长沙410208 [2]湖南中医药大学国家重点学科中医诊断学湖南省重点实验室,长沙410208

出　　处：《世界中医药》2025年第4期684-690,共7页World Chinese Medicine

基　　金：国家自然科学基金面上项目(81973753);湖南省自然科学基金项目(2022JJ30433)。

摘　　要：冠状动脉粥样硬化性心脏病(CHD)是临床表现以心肌缺血、缺氧为主要病理特点的一类心血管疾病。目前,关于冠心病形成发展的微观生物学基础研究共识包括糖脂代谢紊乱、氧化应激、内皮损伤、凝血系统异常等。p38促分裂原活化的蛋白激酶(p38MAPK)信号通路与细胞增殖、分化、凋亡以及机体的生长、代谢、炎症反应等机制密切相关,可以改善血管内皮损伤、血管平滑肌细胞增殖、心肌损伤、血小板活化、脂质代谢。中医药通过化痰、祛瘀、补虚、通滞,燮理气血,调理脏腑阴阳以论治CHD,能够通过影响p38MAPK治疗CHD。随着中药药理研究的发展,具有降低血脂浓度,减少泡沫细胞形成,减轻炎症反应,调节细胞凋亡,改善心肌缺血等的中药单体和中药复方已证实能通过调控p38MAPK信号通路治疗CHD。Coronary artery atherosclerotic heart disease(CHD)is a cardiovascular disease characterized by myocardial ischemia and hypoxia as its main pathological features.Current consensus on the micro-biological basis for the formation and development of CHD includes dysregulation of glucose and lipid metabolism,oxidative stress,endothelial injury,and coagulation system abnormalities.The p38 mitogen-activated protein kinase(p38MAPK)signaling pathway is closely related to mechanisms such as cell proliferation,differentiation,apoptosis,and processes involving growth,metabolism,and inflammation.It plays a role in improving endothelial injury,vascular smooth muscle cell proliferation,myocardial injury,platelet activation,and lipid metabolism.Traditional Chinese medicine(TCM)treats CHD by resolving phlegm,removing blood stasis,tonifying deficiency,unblocking stagnation,regulating qi and blood,and balancing the yin and yang of the organs.TCM can influence p38MAPK signaling pathways to treat CHD.With the development of pharmacological research in Chinese medicine,various Chinese herbal monomers and compound formulas have been confirmed to regulate the p38MAPK signaling pathway,lowering blood lipid levels,reducing foam cell formation,alleviating inflammatory response,modulating cell apoptosis,and improving myocardial ischemia,thus offering potential therapeutic effects for CHD.

关 键 词：冠状动脉粥样硬化性心脏病 p38促分裂原活化的信号通路 促分裂原活化的蛋白激酶 中药单体 中药复方 药理学 研究进展 中医药干预 

分 类 号：R25[医药卫生—中医内科学] R54[医药卫生—中医学]