代谢重编程与抗肿瘤药物耐药的关系  

Relationship between metabolic reprogramming and anti-tumor drug resistance

作　　者：陈奕文 张雄飞 CHEN Yiwen;ZHANG Xiongfei(The First Clinical Medical College,Nanjing University of Chinese Medicine,Nanjing 210023,China;School of Medicine,Nanjing University of Chinese Medicine,Nanjing 210023,China)

机构地区：[1]南京中医药大学第一临床医学院,江苏南京210023 [2]南京中医药大学医学院,江苏南京210023

出　　处：《药学研究》2025年第4期371-376,共6页Journal of Pharmaceutical Research

基　　金：江苏省“十四五”重点学科(生物学)建设基金项目(No.035091005023)。

摘　　要：肿瘤的恶化进程与其独有的异常能量代谢有着密切的关系。为适应快速增殖所带来的对物质、能量以及氧化还原能力的更高需求,肿瘤细胞会对其代谢途径进行重新编程,从而引发耐药性。本文旨在分析葡萄糖代谢、谷氨酰胺代谢和脂质代谢在肿瘤细胞能量代谢中的作用,探讨代谢重编程与肿瘤药物耐药性之间的关系并进行总结与讨论。这对于从分子角度探索肿瘤耐药机制具有重要意义,为肿瘤治疗及其患者预后开辟新途径。The progression of cancer is closely related to its unique abnormal energy metabolism.To meet the higher demands for materials,energy,and redox power for rapid proliferation,tumor cells undergo metabolic reprogramming of their metabolic pathways,thereby inducing drug resistance.This article aimed to analyze the roles of glucose metabolism,glutamine metabolism,and lipid metabolism in the energy metabolism of tumor cells,explore the relationship between metabolic reprogramming and drug resistance in tumor therapy,and provide a summary and discussion.This holds significant importance for exploring the mechanisms of tumor drug resistance from a molecular perspective,opening up new avenues for tumor treatment and prognosis for patients.

关 键 词：代谢重编程 肿瘤耐药 葡萄糖代谢 谷氨酰胺代谢 脂质代谢 

分 类 号：R979.1[医药卫生—药品]