含银离子凝胶联合高压氧治疗在糖尿病足部溃疡患者中的治疗效果  

Efficacy of Silver Ion Gel Combined with Hyperbaric Oxygen Therapy in Patients with Diabetic Foot Ulcers

作　　者：李振堂 陈卓 谢天 Li Zhentang;Chen Zhuo;Xie Tian(Department of Wound Repair,First Affiliated Hospital of Nanyang Medical College,Henan,Nanyang 473000,China)

机构地区：[1]南阳医学高等专科学校第一附属医院创面修复科,河南南阳473000

出　　处：《哈尔滨医药》2025年第2期26-29,共4页Harbin Medical Journal

摘　　要：目的探究含银离子凝胶联合高压氧治疗在糖尿病足部溃疡患者中的治疗效果。方法纳入接受高压氧治疗方案的糖尿病足部溃疡患者48例为对照组,另外选取同期47例在对照组基础上联合使用含银离子凝胶治疗的患者为观察组。对照组接受常规治疗和局部的高压氧治疗方案,观察组在对照组的基础上联合使用含银离子凝胶。比较两组疗效、下肢微循环及血流动力学指标、溃疡面积、创面肉芽情况、皮氧分压、皮温、踝肱指数、血清指标及不良反应。结果观察组的治疗总有效率较对照组显著更高(P<0.05);治疗后,观察组TcPO_(2)、足背TcPO_(2)、足背动脉血流速度、足背动脉内径则高于对照组(P<0.05);观察组患者的溃疡面积长径、短径均优于对照组,并且观察组创面肉芽新鲜占比显著高于对照组(P<0.05);两组患者经过治疗后,皮氧分压、皮温以及踝肱指数均得到明显的改善,且观察组比对照组改善程度更为显著(P<0.05);治疗后,观察组白细胞介素-6(IL-6)、中性粒细胞、超敏C反应蛋白(Hs-CRP)水平相较于对照组显著更低(P<0.05);两组不良反应方面的比较差异无统计学意义(P>0.05)。结论含银离子凝胶联合高压氧治疗在糖尿病足部溃疡患者中具有显著的治疗效果,能改善患者的下肢微循环和血流动力学指标,促进溃疡愈合,降低炎症反应,且不良反应少,值得推广。Objective To investigate the efficacy of silver ion gel combined with hyperbaric oxygen therapy in patients with diabetic foot ulcers.Methods A total of 48 patients who received hyperbaric oxygen therapy were included as the control group,while another 47 patients treated with silver ion gel in addition to the same treatment served as the observation group.The control group(n=48)underwent conventional treatment and local hyperbaric oxygen therapy,whereas the observation group(n=47)received additional silver ion gel application.The efficacy,lower limb microcirculation and hemodynamic parameters,ulcer size,granulation tissue condition,transcutaneous oxygen pressure(TcPO_(2)),skin temperature,ankle-brachial index,serum markers,and adverse reactions were compared between the two groups.Results The overall efficacy rate was significantly higher in the observation group(91.49%)than in the control group(75.00%,P<0.05).Post-treatment,the observation group showed significantly better results in TcPO_(2)(59.41±3.18),dorsal foot TcPO_(2)(48.46±3.46),dorsal foot artery flow velocity(18.65±5.10 cm/s),and dorsal foot artery diameter(0.18±0.05 cm,all P<0.05).Ulcer dimensions(length 2.62±0.36 cm,width 1.85±0.33 cm)and proportion of fresh granulation tissue(87.23%)were also superior in the observation group(all P<0.05).Both groups experienced significant improvements in skin oxygen pressure,skin temperature,and ankle-brachial index,with more pronounced effects observed in the observation group(P<0.05).Additionally,post-treatment levels of interleukin-6(IL-6)(8.79±1.35 ng/L),neutrophils(7.92±1.33109/L),and high-sensitivity C-reactive protein(Hs-CRP)(1.72±0.36 mg/L)were significantly lower in the observation group(P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion The combination of silver ion gel and hyperbaric oxygen therapy is highly effective for diabetic foot ulcers,improving lower limb microcirculation and hemodynamics,promoting ulcer healing,reducing inflammato

关 键 词：含银离子凝胶 高压氧 联合 糖尿病足部溃疡 疗效 

分 类 号：R587.1[医药卫生—内分泌]