含氟材料在抗生素检测中的应用  

Application of Fluorinated Materials in the Detection of Antibiotics

作　　者：王蕊 隋磊 刘轩语 姜学海 宋志花 WANG Rui;SUI Lei;LIU Xuan-yu;JIANG Xue-hai;SONG Zhi-hua(School of Pharmacy,Yantai University,Yantai 264005,China;Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong,Yantai University,Yantai 264005,China;Key Laboratory of Molecular Pharmacology and Drug Evaluation,Ministry of Education,Yantai University,Yantai 264005,China)

机构地区：[1]烟台大学药学院,山东烟台264005 [2]烟台大学新型制剂与生物技术药物研究山东省高校协同创新中心,山东烟台264005 [3]烟台大学分子药理和药物评价教育部重点实验室,山东烟台264005

出　　处：《化学试剂》2025年第5期84-91,共8页Chemical Reagents

基　　金：国家自然科学基金项目(22404143);山东省自然科学基金资助项目(ZR2024QB032)。

摘　　要：目前,由于抗生素滥用,食品和环境中的抗生素残留污染已经成为一个世界性问题。开发准确、实时、高通量、简便、经济的检测方法以评估食品和生物样品中的抗生素残留显得尤为迫切。随着纳米技术的不断发展,纳米材料在医疗和检测等方面得到广泛应用。基于纳米材料建立的抗生素检测方法可以克服传统检测方法灵敏度低、检测速度慢等缺点,将碳基纳米材料引入生物传感器,可以显著放大各类生物传感器的信号,增强分析物与受体之间的相互作用,提高灵敏度和选择性。此外,在纳米材料中引入氟可以增强碳基纳米材料中碳的电负性,使其与周围溶剂发生相互作用,增加电荷载流子密度和偶极子相互作用,降低表面能,从而改善材料的稳定性以及电化学性能。结合近年来国内外相关文献,总结了纳米材料的类型及特点,对含氟纳米材料检测抗生素的方法进行了综述,主要包括荧光碳点、比色法和表面增强拉曼散射(SERS)等。同时也阐述了含氟材料的预处理方法以及其在色谱固定相中的应用和发展前景。Up to now,antibiotic residue in foods and environmental matrices is a global concern caused by the extensive overuse of antibiotics.The development of precise,real-time,high-throughput,affordable,and user-friendly detection techniques is desperately needed for the quick evaluation of antibiotic residues in biological and food samples.Nanomaterials have several uses in medical detection and treatment as a result of the ongoing development of nanotechnology.Low sensitivity and sluggish detection rates are two drawbacks of conventional detection techniques,that can be addressed by nanomaterial-based detection techniques.Adding carbon-based nanomaterials to biosensors can improve sensitivity and selectivity,improve the interaction between analytes and receptors,and greatly increase the signals of different biosensors.Furthermore,fluorine can be added to carbon-based nanomaterials to increase the electronelectronicity of the carbon atom,interact with the surrounding solvent,increase the charge carrier density and dipole interaction,and decrease the surface energy.These changes improve the materials′stability and electrochemical characteristics.The types and properties of nanomaterials were compiled based on recent domestic and international literature,and the techniques for using fluorinated nanomaterials to detect antibiotics,such as fluorescent carbon dots,colorimetry,and surface-enhanced Raman scattering(SERS)were reviewed.The pretreatment procedure for fluorine-containing materials is also described,along with its possible applications and developments in the chromatographic stationary phase.

关 键 词：含氟材料 抗生素 纳米材料 色谱固定相 表面增强拉曼散射 磁性固相萃取 

分 类 号：O65[理学—分析化学]