中医药治疗变应性鼻炎疗效的生物标志物研究进展  

Research progress on biomarkers of traditional Chinese medicine in the treatment of allergic rhinitis

作　　者：周荷青 申琪 ZHOU Heqing;SHEN Qi(Henan University of Chinese Medicine,Zhengzhou 450046,Henan,China;First School of Clinical Medicine,Henan University of Chinese Medicine,Zhengzhou 450046,Henan,China)

机构地区：[1]河南中医药大学,河南郑州450046 [2]河南中医药大学第一临床医学院,河南郑州450046

出　　处：《山东大学耳鼻喉眼学报》2025年第2期168-176,共9页Journal of Otolaryngology and Ophthalmology of Shandong University

基　　金：2020-2021年度河南省中医药科学研究专项课题(20-21ZY1013);河南省中医药科学研究专项课题(2021JDZY011)。

摘　　要：变应性鼻炎(allergic rhinitis, AR)是耳鼻喉科常见病,以鼻痒、阵发性喷嚏、流清涕、鼻塞为特征,发病率逐年上升,已经成为主要的呼吸道慢性炎性疾病。中医药(traditional Chinese medicine, TCM)治疗不仅能有效控制AR患者的症状,而且具有预防作用和远期疗效。目前针对其疗效评估仍以症状体征量表为主,主观性强,因此找到能够客观评估疗效的生物学指标刻不容缓。论文梳理了近年来TCM治疗AR疗效的生物学标志物的相关文献,发现鼻分泌液和血清免疫学指标中多种细胞因子和免疫细胞水平的改变与TCM治疗AR的机制有关,可能作为评估TCM疗效的潜在生物标志物,希望为TCM治疗变应性鼻炎提供证据支持和循证学依据。Allergic rhinitis(AR)is a common disease in otolaryngology.It is characterized by nasal itching,paroxysmal sneezing,runny nose,and nasal congestion.The incidence rate has been gradually increasing and it has become a major chronic inflammatory disease of the respiratory tract.Traditional Chinese medicine(TCM)treatment can not only effectively control the symptoms of patients with AR,but also has preventive and long-term effects.At present,the evaluation of efficacy is still based on the symptom,which are subjective.Therefore,biological indicators that can objectively evaluate the efficacy are needed with urgency.This paper reviews the relevant recent literature on the biological markers of the efficacy of TCM in the treatment of AR.We show that the changes in various cytokines and immune cells in nasal secretions and serum immunological indexes are related to the mechanism of TCM in the treatment of AR.Therefore,they can be used as potential biomarker to evaluate the efficacy of TCM,and provide evidence-base for the treatment of allergic rhinitis with TCM.

关 键 词：中医药 变应性鼻炎 生物标志物 鼻分泌液 血清免疫学 呼吸道慢性炎性疾病 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]