嗜酸性粒细胞在心血管疾病中的研究进展  

Research progress of eosinophils in cardiovascular diseases

作　　者：邓智勇 杨崇哲 DENG Zhiyong;YANG Chongzhe(Cardiovascular Department of Geriatrics,the Second Affiliated Hospital of South China University of Technology,Guangzhou First People’s Hospital,Guangzhou 510180,China)

机构地区：[1]华南理工大学附属第二医院(广州市第一人民医院)老年医学科心血管内科,广东广州510180

出　　处：《广州医药》2025年第4期429-438,共10页Guangzhou Medical Journal

基　　金：国家自然科学基金(82170234,82400301)。

摘　　要：嗜酸性粒细胞(EOS)作为过敏反应中关键的先天免疫细胞,在心血管疾病的发生与发展进程中也扮演着至关重要的角色。大量证据显示,血液EOS计数与诸多心血管疾病之间存在紧密联系,但临床研究得出的结论不尽相同。基础研究发现,EOS一方面可通过释放白细胞介素-4(IL-4)、IL-13及阳离子蛋白等细胞因子,对心肌梗死、心肌肥厚、心力衰竭或腹主动脉瘤发挥保护作用;另一方面,EOS表达的阳离子蛋白和血小板活化因子会促进平滑肌细胞增殖和钙化,进而加速动脉粥样硬化的形成。因此,EOS在不同心血管疾病中所发挥的作用存在差异,这与疾病的演变进程、EOS的数量均密切相关。本文对现有的临床和基础研究成果进行汇总,阐述EOS在各类心血管疾病中的不同作用。Eosinophils(EOS),as key innate immune cells in allergic reactions,play a crucial role in the occurrence anddevelopment of cardiovascular diseases.Ample evidence shows that the count of blood EOS is closely related to many cardiovasculardiseases.However,the conclusions drawn from clinical studies are inconsistent,and these contradictory observational results stillcannot be reasonably explained so far.Basic research has found that,on the one hand,EOS can exert protective effects on myocardialinfarction,myocardial hypertrophy,heart failure,or abdominal aortic aneurysm by releasing cytokines such as interleukin-4(IL-4),IL-13,and cationic proteins;on the other hand,the cationic proteins and platelet activating factors expressed by EOS canpromote the proliferation and calcification of smooth muscle cells,thereby accelerating the formation of atherosclerosis.Therefore,the roles played by EOS in different cardiovascular diseases vary,which is closely related to the evolution process of the disease andthe number of EOS.This article will summarize the existing clinical and basic research results to elaborate the different roles of EOS invarious cardiovascular diseases.

关 键 词：嗜酸性粒细胞 心血管疾病 阳离子蛋白 

分 类 号：R54[医药卫生—心血管疾病]