铁过载与胰岛β细胞功能障碍的研究进展  

Research Progress on Iron Overload and Pancreatic β-Cell Dysfunction

作　　者：吴燕燕 黄玫 姜文灿 张梅[1] Wu Yanyan;Huang mei;Jiang Wencan;Zhang Mei(Department of Endocrinology,the First Hospital of Nanjing Medical University,Nanjing 210029,Jiangsu,China)

机构地区：[1]南京医科大学第一附属医院内分泌科,南京210029

出　　处：《中华老年医学杂志》2025年第4期429-434,共6页Chinese Journal of Geriatrics

基　　金：国家自然科学基金项目(82370828,81974103)。

摘　　要：胰岛β细胞功能障碍是2型糖尿病(type 2 diabetes mellitus,T2DM)发生发展的关键因素之一。近年来,研究发现铁过载是T2DM的危险因素,过量的铁可以通过氧化应激、线粒体功能障碍、胰岛β细胞数量减少等多种途径介导β细胞功能障碍,影响胰岛素的合成、分泌和释放,从而参与T2DM的发生发展。本文就铁过载与胰岛β细胞功能障碍的研究进展进行综述。Pancreaticβ-cell dysfunction is a critical factor in the pathogenesis of type 2 diabetes mellitus(T2DM).Recent studies have identified iron overload as a significant risk factor for T2DM,wherein excess iron contributes toβ-cell dysfunction through multiple pathways,including oxidative stress,mitochondrial dysfunction,and a reduction in the number of pancreaticβ-cells.These mechanisms adversely affect insulin synthesis,secretion,and release.This review aims to summarize the recent advancements in understanding the relationship between iron overload and pancreaticβ-cell dysfunction.

关 键 词：铁过载 胰岛Β细胞功能障碍 2型糖尿病 

分 类 号：R587.1[医药卫生—内分泌]