脑类淋巴系统AQP4极化分布的调控机制研究进展  

Research progress on regulatory mechanism of AQP4 polarization distribution in glymphatic system

作　　者：林雪玲 李英[1,2] 任家乐 张艳军[1,2,3,4] 庄朋伟[1,2,3,4] 尹清晟 LIN Xue-ling;LI Ying;REN Jia-le;ZHANG Yan-jun;ZHUANG Peng-wei;YIN Qing-sheng(National Key Laboratory of Modern Chinese Medicine Creation,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Haihe Laboratory of Modern Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China;National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 300193,China)

机构地区：[1]天津中医药大学现代中药创制全国重点实验室,天津301617 [2]天津中医药大学现代中医药海河实验室,天津301617 [3]天津中医药大学第一附属医院,天津300193 [4]天津中医药大学国家中医针灸临床医学研究中心,天津300193

出　　处：《中国药理学通报》2025年第5期811-815,共5页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 82174112);现代中医药海河实验室科技项目(No 22HHZYSS00015)。

摘　　要：脑类淋巴系统(glymphatic system,GS)是大脑特有的毒性物质清除系统,对维持中枢神经系统微环境稳态至关重要。位于星形胶质细胞终末端足的水通道蛋白4(aquaporin 4,AQP4)的极化分布影响GS功能,且参与多种神经退行性疾病的病理进展,但AQP4极化分布的详细调控机制目前仍未被系统归纳总结。因此,该文重点从肌营养不良蛋白-糖蛋白复合物与基底膜终足复合体成分完整性角度,系统梳理了调控AQP4极化分布机制,并且总结当前靶向调控AQP4极化分布的潜在药物及非药物疗法,旨在为靶向调控AQP4极化,防治神经退行性疾病提供新靶点参考和理论依据。The glymphatic system(GS)is a unique toxic substance clearance system in brain,which is very important for maintaining the microenvironment stability of the central nervous system.The polarization distribution of aquaporin 4(AQP4)located in the terminal foot of astrocytes affects the function of GS and participates in the pathological progress of many neurodegenerative diseases,but the detailed regulation mechanism of AQP4 polarization distribution has not been systematically summarized.Therefore,this paper systematically combs the mechanism of regulating the polarization distribution of AQP4 from the perspective of the composition integrity of dystrophin-glycoprotein complex(DGC)and basement membrane foot complex,and summarizes the potential drug and non-drug therapies for targeted regulation of AQP4 polarization distribution at present,aiming at providing new target reference and theoretical basis for targeted regulation of AQP4 polarization to prevent and treat neurodegenerative diseases.

关 键 词：类淋巴系统 星形胶质细胞 水通道蛋白4 极化分布 肌营养不良蛋白-糖蛋白复合物 基底膜 

分 类 号：R322.2[医药卫生—人体解剖和组织胚胎学] R322.81[医药卫生—基础医学] R329.24R341R745.7R977.6