舒心平中龙脑及异龙脑质量分数的气相色谱定量测定  

QUANTITATIVE ANALYSIS OF THE BORNEOL AND ISOBORNEOL IN CHINESE MEDICINE SHUXINPING BY GC AND GC-MS

作　　者：丁雅韵[1] 谢孟峡[1] 陈世忠[2] 

机构地区：[1]北京师范大学分析测试中心,北京100875 [2]北京大学药学院,北京100083

出　　处：《北京师范大学学报（自然科学版）》2002年第6期782-785,共4页Journal of Beijing Normal University(Natural Science)

基　　金：国家自然科学基金资助项目 (2 9837190 )

摘　　要：用气相色谱法和气相色谱 -质谱联用法对舒心平的有效成分龙脑及异龙脑的提取液进行测定 [1] .对 4种提取溶剂 (即正己烷、乙酸乙酯、二氯甲烷、乙醇 )和 3种提取方法 (冷浸、超声、回流 )的选择进行了实验研究 ,结果发现 :乙醇为提取溶剂用超声的方法提取效率最高 .以薄荷醇为内标 ,对 3批舒心平样品中龙脑和异龙脑的质量分数的测定结果表明 ,气相色谱定量分析方法的重现性和样品的稳定性均良好 ;龙脑组分标准曲线的线性相关系数达到 1.0 0 0 ,加标回收率在99.12 %～ 10 1.4 %之间 .Borneol and isoborneol, the effective constituent in Chinese Medicine Shuxinping are quantitatively analyzed by GC and GC-MS with hexahydrothymol as an internal standard. By comparison of three extraction methods and four extraction solvents, it is found that ultrasonic extraction method using ethanol as extraction solvent has the highest efficiency. The result shows that the repeatability of GC method and the stability of Shuxinping are perfect. The coefficient of linear correlation for borneol's calibration curve reaches to 1. 000, the average recoveries are between 99. 12% and 101. 4%.

关 键 词：质量分数 定量测定 气相色谱法 龙脑 异龙脑 舒心平 抗冠心病药物 

分 类 号：R972[医药卫生—药品] R927.2[医药卫生—药学]