灰黄霉素在Co离子注入修饰电极上的电化学行为的研究  

STUDY ON THE ELECTROCHEMICAL BEHAVIOR OF GRISEOFULVIN AT A Co-GC ION IMPLANTATION MODIFIED ELECTRODE

作　　者：尚军[1] 邵娜[1] 胡劲波[1] 李启隆[1] 

机构地区：[1]北京师范大学化学系,北京100875

出　　处：《北京师范大学学报（自然科学版）》2002年第6期790-794,共5页Journal of Beijing Normal University(Natural Science)

基　　金：国家自然科学基金资助项目 (2 9875 0 0 3)

摘　　要：灰黄霉素在 0 .1mol.L-1HAc- Na Ac缓冲溶液 (p H=5 .86)中 ,于 Co- GC离子注入修饰电极上 ,形成一良好的线性扫描伏安还原峰 ,峰电位 Ep=- 0 .63V(vs.SCE) .峰电流 ip 与灰黄霉素浓度在 5 .0× 10 -9～ 1.1× 10 -6mol.L-1范围内成线性关系 ,相关系数为 0 .9998,检测限可达2 .0× 10 -9mol.L-1,可用于痕量物质的测定 .用线性扫描与循环伏安法等手段研究了体系的性质 ,实验表明电极反应为不可逆吸附过程 .用 AES和 XPS对电极表面进行了表征 .With Co-GC ion implantation modified electrode, in 0. 1 mol·L -1 HAc-NaAc buffer solution (pH=5. 86),a sensitive reduction peak of griseofulvin is obtained by linear-sweep voltammetry. The peak potential is -0. 63 V(vs.SCE). The peak current is proportional to the concentration of griseofulvin in the range of 5. 0×10 -9 to 1. 0×10 -6 mol·L -1 with a detection limit of 2. 0×10 -9 mol·L -1. This method can be applied successfully for the trace determination of griseofulvin. The electrochemical behavior of the system is also studied by cyclic voltammetry, and the experiment results show that the electrode process is irreversible with adsorption. AES and XPS are used to characterize the surface of ion implantation modified electrode.

关 键 词：Co离子注入 修饰电极 电化学行为 灰黄霉素 线性扫描法 循环伏安法 不可逆吸附过程 抗生素类药物 

分 类 号：R978.1[医药卫生—药品] R914[医药卫生—药学]