补气通络方对大鼠坐骨神经急性挤压伤后氧自由基的影响  

Effect of Buqi Tongluo Prescription on Oxygen Free Radicals in Rats with Acute Crush Injury of Sciatic Nerve

作　　者：杨志东[1] 韩清明[1] 何振辉[1] 梁德[1] 梁笃[1] 潘静华[1] 姚珍松[1] 

机构地区：[1]广州中医药大学第一附属医院二骨科,广州510405

出　　处：《广州中医药大学学报》2002年第4期295-297,共3页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：广东省中医药管理局资助课题(编号:99136)

摘　　要：【目的】探讨补气通络方(由黄芪、当归、丹参、川芎、人参组成)对周围神经缺血再灌注损伤的保护作用及其作用机理。【方法】将72只右坐骨神经急性挤压伤模型大鼠,随机分成补气通络胶囊组、模型组。每组36只,分别于造模后1d、3d、7d、14d、28d、56d各取出6只,检测坐骨神经氧自由基(OFR)相对浓度、超氧化物歧化酶(SOD) 含量、丙二醛(MDA)含量。【结果】补气通络方组OFR相对浓度、SOD含量、MDA含量均较模型组有改善(P<0.05或P<0.01)。【结论】补气通络方对周围神经缺血再灌注损伤有保护作用。[Objective] To investigate the protective effect of Buqi Tongluo Prescription (BTP, composed of Radix Astragali, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong and Radix Ginseng) on peripheral nerve with ischemia/reperfusion injury and to explore its mechanism. [Methods]Seventy - two rats with acute crush injury of sciatic nerve were randomly allocated to BTP group (Group A, n = 36) and model group (Group B, n = 36) .Contents of oxygen free radicals (OFR) , superoxide dismutase (SOD) and malondialdehyde(MDA) in sciatic nerve were detected in 1, 3,7, 14, 28,and 56 day(s) after modeling. [Results]Contents of OFR, SOD and MDA were improved in Group A ( P <0.05 or P<0.01 as compared with Group B) . [ Conclusion ] BTP exerts a protective effect on peripheral nerve with ischemia/reperfusion injury.

关 键 词：补气通络方 大鼠 氧自由基 坐骨神经损伤 超氧化物歧化酶 

分 类 号：R285.5[医药卫生—中药学] R269.[医药卫生—中医学]