塔里木盆地子午沙鼠鼠疫菌感受性实验  

Susceptibility of Merions meridianus in Tarim Basin to Yersinia pestis

作　　者：林纪春[1] 徐菲莉 张晓雪[1] 冯玉明[1] 王诚[1] 雷刚[1] 彭奕[1] 钱存宁[1] 

机构地区：[1]新疆疾病预防控制中心,新疆乌鲁木齐830002 [2]新疆维吾尔自治区中医院,新疆乌鲁木齐830002

出　　处：《地方病通报》2002年第4期23-25,共3页Endemic Diseases Bulletin

基　　金：国家自然科学基金资助 (30 0 60 0 76)

摘　　要：为研究塔里木盆地子午沙鼠 (Merionesmeridianus)对鼠疫菌的感受性、敏感性 ,用分离自新疆南天山乌恰灰旱獭体内的鼠疫强毒菌 2 110 6号 ,以 1× 10 1 ～ 1× 10 9个菌皮下接种从塔里木盆地捕获的子午沙鼠。1× 10 1 个菌可引起个别子午沙鼠死亡 ,1× 10 7个菌可使接种的子午沙鼠全部死亡。感染鼠的 95 %在 7d内死亡 ,1只鼠第 4 7d死亡细菌学培养仍为阳性。对初次感染后的存活鼠 ,再次接种 1× 10 8个菌 ,其耐受性有所增强。显示塔里木盆地子午沙鼠对从灰旱獭分离的强毒菌株敏感性较高 ,个体差异较大 。To study the susceptibility and sensitivity of Merions meridianus in Tarim Basin to Yersinia pestis, highly virulent strain of Y.pestis, (strain No. 21106) isolated from Marmota baibacina in Uqia County in southern part of Tianshan Mountains,Xinjiang, was used to inoculate subcutaneously M.meridianus captured in Tarim Basin in the doses of 1×10 1～1×10 9 plague bacilli per mL. The dose of 1×10 1 plague bacilli led to death in individual animals,that of 1×10 7 bacilli to death in all animals inoculated, and 95% of animals infected died within 7 days. One animal which died on the 47th day was still positive in bacterial culture.Survival animals after initial infection showed increased tolerance following re inoculation with 1×10 8 plague bacilli.The results showed that M.meridianus in Tarim Basin has higher sensitivity to highly virulent strain of Y. pestis isolated from M. baibacina , greater individual difference and higher tolerance.

关 键 词：塔里木盆地 子午沙鼠 鼠疫菌感受性 鼠疫菌感染 实验研究 

分 类 号：R378.61[医药卫生—病原生物学] R516[医药卫生—基础医学]