大鼠DBI及其合并SBI后第Ⅲ组mGluRs激动剂L-AP4神经保护作用  

Neuroprotective effects of an agonist of group Ⅲ mGluRs L-AP4 on diffuse brain injuries with secondary brain insults in rats

作　　者：白红民[1] 费舟[1] 章翔[1] 李志刚[1] 公方和[1] 刘先珍[1] 梁景文[1] 

机构地区：[1]第四军医大学西京医院全军神经外科研究所,陕西西安710033

出　　处：《第四军医大学学报》2002年第23期2125-2128,共4页Journal of the Fourth Military Medical University

基　　金：全军"九五"医学科研规划基金 (98M1 0 1 )

摘　　要：目的　探讨Ⅲ组mGluRs激动剂L AP4对弥漫性脑损伤 (diffusebraininjury ,DBI)及其合并二次脑损伤 (secondarybraininsult,SBI)后损伤脑组织的神经保护作用 .方法　在单纯DBI及合并SBI后 ,脑室注射L AP(10 0 μmol·L- 1 ,10 μL)或生理盐水 (10 μL) ,观察大鼠行为、脑组织含水量及皮层损伤神经元数变化 .结果　L AP4对DBI后大鼠死亡率、皮层损伤神经元数量及脑组织含水量无明显影响 (P >0 0 5 ) ;但可降低合并SBI组大鼠死亡率、减轻合并SBI后的脑水肿程度 ,减少神经元损伤数量 (P <0 0 5 ) .结论　L AP4对DBI合并SBI后损伤脑组织有一定的保护作用 .AIM To study the neuroprotective effects of L AP4 on diffuse brain injury (DBI) and secondary brain injury (SBI). METHODS Animals in the treatment group were all injected intracerebroventricularly with L AP4 (100 mmol·L -1 , 10 μL) 1 hour after injuries, while animals in the control group were all injected with normal saline. Then the rats were examined for the motor and cognitive performance 12 hours after injuries. The water contents and the numbers of injured neurons were counted at different intervals post injuries.RESULTS Although L AP4 had no obvious effects on the morality rate, the water contents in the frontal cortex and the damaged neurons in the parietal cortex of the rats with DBI alone, it did reduce them in the rats with DBI coupled with SBI. CONCLUSION The results of this study indicate that L AP4 provides remarkable protection against the damage exacerbated by secondary injury.

关 键 词：脑损伤 MGLUR L-AP4 神经保护作用 

分 类 号：R651.15[医药卫生—外科学]