大骨节病区儿童尿羟脯氨酸、氨基多糖排泄量与尿硒关系的分析  

Investigation on the Relationship Between Urinary Selenium and Urinary Excretion of Hydroxyproline and Glycosaminoglycan in Children With Kashin-Beck Disease

作　　者：李斯纯[1] 莫晓燕[1] 张矢远[1] 于志道[1] 李永春 

机构地区：[1]西安医科大学地方性骨病研究所,西安市710061

出　　处：《地方病通报》1992年第2期73-76,共4页Endemic Diseases Bulletin

摘　　要：本文观察了大骨节病区患儿、非患儿和非病区儿童的尿羟脯氨酸和氨基多糖组分的排泄量与尿硒水平的关系,结果表明患儿的尿硒、羟脯氨酸和氨基多糖排泄量不仅低于非病区儿童,也低于病区非患儿,当尿硒低于2.00μg/24h时,硒对尿软骨代谢指标有显著影响,高于2.00μg/24h时,则与上述指标无明显相关关系。这些结果说明,病区儿童的低硒状态是导致软骨代谢异常的重要因素之一。In order to elucidate the relatioship between urinary selenium (Se) and urinary excretion of hydroxyproline and glycosaminoglycan in children with Kashin-Beck disease (KBD), we classified the children with KBD and healthy children in endemic area and non-endemic area into subgroups in terms of their urinary Se contents. The results showed that, when urinary Se was below 2.00μg / 24h, urinary excretion of hydroxyproline and glycosaminoglycan of the children with KBD was not only lower than that of healthy children in non-endemic area, but also lower than that of healthy children in endemic area. However, the above findings didn't occur when urinary Se was over 2.00μg/24h. Our observation indicated that low Se nutritious condition was responsible for the change of urinary excretion of hydroxyproline and glycosaminoglycan in the children with KBD

关 键 词：骨节病 硒 尿羟脯氨酸 尿氨基多糖 

分 类 号：R684.102[医药卫生—骨科学]