双链RNA在基因沉默中的作用  

The Function of Double-Stranded RNA in Gene Silencing

作　　者：汤富酬[1] 李成建[1] 薛友纺[1] 

机构地区：[1]北京大学生命科学学院细胞生物学及遗传学系,北京100871

出　　处：《中国生物化学与分子生物学报》2002年第6期659-663,共5页Chinese Journal of Biochemistry and Molecular Biology

基　　金：国家自然科学基金资助 (No .3 0 0 70 414 )~~

摘　　要：介绍依赖于同源识别的基因沉默 .依赖于同源识别的基因沉默 ,是指向生物体内导入外源核酸时引起相应序列的内源基因的表达被特异性抑制的一种基因调控现象 .基因沉默分为转录基因沉默和转录后基因沉默 ,二者都通过双链RNA介导 .它们是真核生物中普遍存在的抵抗病毒入侵、抑制转座子活动、调控基因表达的监控机制 .这些机制具有巨大的应用前景 .The homology dependent gene silencing was introduced. It is sequence specific inhibition of corresponding endogenous gene expression induced by foreign nucleic acid molecules. Gene silencing includes transcriptional gene silencing and post transcriptional gene silencing. They are both directed by double stranded RNA. And gene silencing is a common gene regulation mechanism against virus invasion and activation of transposable elements, which are widespread in nearly all eukaryotic organisms. It will have invaluable importance in the future.

关 键 词：小干涉RNA 甲基化 双链RNA 基因沉默 作用 

分 类 号：Q78[生物学—分子生物学]