非NMDA受体的细胞内调控及其机制  

Intracellular modulation and its mechanisms of the non-NMDA receptors

作　　者：王婧[1] 伍龙军[1] 徐天乐[1] 

机构地区：[1]中国科学技术大学生命科学学院神经生物学与生物物理学系,合肥230027

出　　处：《生命科学》2002年第5期257-260,共4页Chinese Bulletin of Life Sciences

基　　金：国家"973"项目(G1999054000);国家杰出青年基金(30125015)

摘　　要：非NMDA受体是AMPA受体和KA受体的统称,其亚基上的胞内C末端上有很多磷酸化脱磷酸化及胞内蛋白的结合位点,这些作用位点与非NMDA受体的调控密切相关。如PKA、PKC、PKG、CaMKⅡ和PTK等蛋白激酶均可调节受体的活性。另外,胞内的一些骨架蛋白和信号蛋白也可与非NMDA受体结合而影响其功能。本文着重综述非NMDA受体的细胞内调控及其机制。Non-NMDA receptors is a general designation of AMPA receptors and KA receptors. Many phosphorylation and dephosphorylation sites as well as the intracellular proteins-binding sites are existed on the C-terminal of the non-NMDA receptor subunits, which are closely related to the modulation of the non-NMDA receptors. For example, many kinds of protein kinases such as PKA, PKC, PKG, CaMK n and PTK can modulate the activity of the receptors. In addition, some scaffolding proteins and signaling proteins are also able to bind to non-NMDA receptors to influence their functions. This review focuses on the intracellular modulation and its mechanisms of non-NMDA receptors.

关 键 词：磷酸化 胞内蛋白 非NMDA受体 细胞内调控 机制 

分 类 号：Q422[生物学—神经生物学]