圆滑番荔枝种子化学成分研究  

Chemical constituents from the seeds of Annona glabra (annonaceae)

作　　者：孙兰[1] 朱久香[1] 余竞光[1] 余冬蕾[1] 李德宇[1] 周立东[1] 

机构地区：[1]中国医学科学院,中国协和医科大学药用植物研究所,北京100094

出　　处：《药学学报》2003年第1期32-36,共5页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目 (2 95 72 0 87)

摘　　要：目的　研究圆滑番荔枝 (Annonaglabra)种子的抗肿瘤活性成分。方法　利用色谱技术分离纯化 ,根据化合物的理化性质和光谱数据鉴定结构。结果　从己烷提取物鉴定 18个化合物 ,其中 14个为番荔素 :glabrencinA(1) ,bullatencin (2 ) ,glabrencinB (3) ,uvariamicin I (4) ,uvariamicin II (5 ) ,uvariamicin III (6 ) ,reticulatain 1(7) ,desacetyluvaricin (8) ,4 deoxyasimicin (9) ,asimicin (10 ) ,bullatacin (11) ,squamocin (12 ) ,motrilin (13) ,cherimolin 2(14 ) ;豆甾醇 (stigmasterol,15 )及脂肪酸酰胺混合物 :棕榈酸酰胺 (palmiticamide ,16 ) ,硬脂酸酰胺 (stearicamide,17)和花生酸酰胺 (arachidicamide ,18)。结论　glabrencinA (1) ,glabrencinB (3)为新番荔素 ;2 ,4～ 7,9,11,13,16～ 18是首次从该植物中分离得到。Aim To study the antitumor active constituents of the seeds from Annona glabra L. (Annonaceae). Methods Various chromatographic techniques were used to separate and purify. Their physicochemical properties and spectral data were used to elucidate the structures. Results Eighteen compounds were isolated and identified from the hexane extract of A.glabra . Fourteen of them were identified as annonaceous acetogenins: glabrencin A (1), bullatencin (2), glabrencin B (3), uvariamicin-I (4), uvariamicin-II (5), uvariamicin-III (6), reticulatain-1 (7), desacetyluvaricin (8), 4-deoxyasimicin (9), asimicin (10), bullatacin (11), squamocin (12), motrilin (13), cherimolin-2 (14). The other four ones were identified as stigmasterol (15), a mixture of fatty acid amides: palmitic amide (16), stearic amide (17) and arachidic amide (18). Conclusion Glabrencin A (1) and glabrencin B (3) are new acetogenins. Compounds 2, 4-7, 9, 11, 13, and 16-18 were identified from this plant for the first time.

关 键 词：化学成分 圆滑番荔枝 番荔枝科 番荔素 抗肿瘤 glabrencin A glabrencin B 

分 类 号：R284.1[医药卫生—中药学] R282.71[医药卫生—中医学]