甲胺磷重复染毒大鼠膈肌损害及突击量氯磷定对其保护作用  

Diaphragmatic lesion in repeated methamidophos intoxicated rats and the protection of concentrated-dose pralidoxime chloride

作　　者：霍书花[1] 田英平[1] 石汉文[1] 苏建玲[1] 佟飞[1] 李星海[1] 扈琳[1] 

机构地区：[1]河北医科大学第二医院急诊科,050000

出　　处：《中国急救医学》2002年第12期690-692,共3页Chinese Journal of Critical Care Medicine

基　　金：河北省教育厅科研基金资助项目 (No 2 0 0 1133)

摘　　要：目的　探讨甲胺磷重复染毒大鼠膈肌损害及突击量氯磷定对其保护作用。方法　对 96只SD大鼠皮下重复注射甲胺磷制备有机磷中毒模型 ,并给予不同治疗—阿托品或阿托品 +突击量氯磷定 ,观察各组大鼠不同治疗情况下 ,染毒后不同时间膈肌组织病理学和超微结构的改变。结果　给予突击量氯磷定治疗组大鼠膈肌病理损害较单用阿托品组轻 ,病变恢复快。结论　急性甲胺磷中毒可致膈肌损害 。Objective To study the morphological changes of diaphragm in repeated methamidophos intoxicated rats and the protection of concentrated-dose pralidoxime chloride.Methods An experimental model of SD rat was made by subcutaneous injection of methamidophos repeatedly,according to the therapy 96 rats were divided into to the control group,the atropine group and atropine +pralidoxime chloride (PAM-Cl) group.To assess the morphological changes of diaphragm at different time from 1 to 12 days.Results All the poisoned rats showed diaphragmatic histologic damage and the damage of the atropine +PAM-Cl group was slighter than that of the atropine group.Conclusion Organophosphate could induce diaphragmatic morphological changes and concentrated-dose pralidoxime chloride could lighten the lesion.

关 键 词：甲胺磷 大鼠 膈肌损害 氯磷定 保护作用 阿托品 有机磷农药中毒 

分 类 号：R595.4[医药卫生—内科学]