月桂氮酮对青藤碱凝胶剂的透皮吸收作用  

Studies on effect of azone on percutaneous absorption of sinomenine gel in vitro

作　　者：张丙宏[1] 张先洲[1] 李杰[2] 蔡海燕 薛承斌 

机构地区：[1]武汉大学人民医院,湖北武汉430060 [2]利川市人民医院,湖北利川445400 [3]武汉大学药学院,毕业生湖北武汉430071

出　　处：《中国医院药学杂志》2002年第12期707-709,共3页Chinese Journal of Hospital Pharmacy

基　　金：湖北省自然科学基金(编号:2001ABD156)

摘　　要：目的:考察不同浓度月桂氮(艹卓)酮(azone)对青藤碱凝胶透皮作用的影响,为青藤碱凝胶剂的处方筛选提供依据。方法:采用改良Franz扩散池,以离体大白鼠皮肤为透皮屏障,配制含不同浓度月桂氮(廿卓)酮的青藤碱凝胶,用HPLC法测定青藤碱的透皮吸收量,结果:青藤碱凝胶含2％azone时透皮吸收最好,其体外累积渗透量及促造速率最大。青藤碱凝胶剂的体外渗透药动学符合Higuchi方程。结论:选择2％azone作为青藤碱凝胶剂的促透剂。OBJECTIVE To investigate the effect of different content of azone on percutaneous absorption of sinomenine gels in vitro, and to decide an amount of azone for the gel. METHODS The transdermal penetration in Franz diffusion apparatus with excised mice skin of sinomenine gels with different content of azone was studied. The content of sinomenine was determined by HPLC. RESULTS The percutaneous absorption of sinomenine gel containing 2% azone was the best. The permeation process of sinomenine gel in vitro could be described by Higuchi's Equation. CONCLUSIONS 2% azone is selected as the enhancer of sinomenine gel.

关 键 词：月桂氮ZHUO酮 青藤碱凝胶剂 透皮吸收 高效液相色谱法 

分 类 号：R965.1[医药卫生—药理学] R944.[医药卫生—药学]