Permanent liver allograft survival Induced by transfusion of apoptotic donor splenocyte without Immunosuppression  

作　　者：YIGAO YUFANGSHI 等 

机构地区：[1]OrganTransplatationDepartment,ZhujiangHospital,FirstMilitaryMedicalUniversity,Guangzhou,China [2]DepartmentofMolecularGeneticsandMicrobiology,UniversityofMedicineandDentistryofNewJers

出　　处：《Cell Research》2002年第3期272-273,共2页细胞研究（英文版）

摘　　要：Recent progress in apoptosis study has revealed that it is not only a process to quietly eliminate excessive cells, but also plays important roles in immune regulation. In the present study, we investigated whether donor apoptotic cell can be used to induce transplant immune tolerance. Dexamethasone (Dex, 3mg/kg/day for 3 days) was injected intraperitoneally into adult Sprawn-Dowley (SD) rats. Splenocytes from those dex-treated rats were isolated and transfused into Wistar adult rats. One week later, Sprawn-Dowley liver were transplanted into the Wistar rats received dex-treated splenocytes. Dex treatment often induces

关 键 词：凋亡供体脾细胞灌注 异体移植肝 长期存活 非免疫抑制 

分 类 号：R657.3[医药卫生—外科学] R617[医药卫生—临床医学]