AMID, an AIF homologous protein, induces caspases-independent apop-tosis  

出　　处：《Cell Research》2002年第3期295-295,共1页细胞研究（英文版）

摘　　要：AIF is a mitochondrial flavoprotein that triggers caspase-independent apoptosis. We cloned and characterized a novel AIF homologous molecule designated as AMID (AIF-homologous Mitochondrion-associated Inducer of Death. AMID lacks a mitochondrial localization sequence but shares significant homology with AIF and NADH-oxidoreductases from bacteria to mammalian species. Immunofluorescent staining and biochemical experiments indicated that AMID was co-localized with mitochondria. Overexpression of

关 键 词：AMID AIF同源蛋白 诱导 caspase酶 非依赖性凋亡 

分 类 号：Q26[生物学—细胞生物学]