Phosphoinositides as ligands of PHD-fingers: implications for chromatin remodeling  

作　　者：ORGOZANI PHILIPKARUMAN SETHFIELD JAMESCHA JENNIFERVILLASENOR VIKRAMRRAO JOANSBRUGGE LEWISCCANTLEY CHERYLLBAIRD BHARATMEHROTRA DAVIDGMYSZKA COLINGFERGUSON GLENNDPRESTWICH 

机构地区：[1]Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA,Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA,Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA,Department of Cell Biology,

出　　处：《Cell Research》2002年第3期297-297,共1页细胞研究（英文版）

摘　　要：Phosphatidylinositol phosphates (PtdInsPs) play critical roles in signal transduction pathways, cytoskele-tal regulation, and vesicular trafficking and are implicated in multiple disease pathways. In the nucleus, PtdlnsPs have been found associated with chromatin, but their specific nuclear-binding proteins have not been identified. In a biochemical screen for PtdInsP-binding proteins, we identified a protein (ING2) containing a Plant Homeodomain (PHD) finger, a motif present in many chromatin- regulatory proteins. We show that the PHD domains of ING2 and of other diverse nuclear proteins bind to the rare PtdInsP species, phosphatidylinositol 5-phosphate (PtdIns(5)P). Further, we provide evidence for a functional

关 键 词：磷酸肌醇 PHD指蛋白 配基 染色质重构型 

分 类 号：Q343.2[生物学—遗传学]