Synthesis of highly concentrated,carrier free ^(188)Re-mercaptoacetyltriglycine  

作　　者：ZHANG Xiu-Li, WANG Yong-Xian, LI Jun-Ling, ZHANG Chun-Fu, WANG Li-Hua,YIN Duan-Zhi(Shanghai Institute of Nuclear Research, the Chinese Academy of Sciences, Shanghai 201800) 

出　　处：《Nuclear Science and Techniques》2002年第4期237-243,共7页核技术（英文）

基　　金：Supported partially by Key Project of Knowledge Innvation Program of the Chinese Academy of Sciences (KJCX1-sw-08)

摘　　要：Chelation of 188Re to compounds such as MAG3 will further reduce the radiation dose to the patient in case of balloon rupture through the rapid excretion from the body. In order to prepare highly concentrated, carrier free 188Re-MAG3, Sbenzoyl mercaptoacetyltriglycine (S-Bz-MAG3) was synthesized, labeled with carrier free 188Re. The overall yield of S-Bz-MAG3 is higher than those published in theliterature. Dependence of the labeling yield of 1ssRe-MAG3 upon concentrations of reducing agent, pH, reaction time, etc. was examined and optimum conditions were confirmed. The concentration procedure was succeeded with Sep-Pak C18 cartridge to obtain highly concentrated 1s8Re-MAG3. In the case of optimun conditions, the labeling yield of 188Re-MAG3 was more than 98%. Radiochemical purity of 188ReMAG3 was more than 92% after 24 hour storage at room temperature.Chelation of 188Re to compounds such as MAG3 will further reduce the radiation dose to the patient in case of balloon rupture through the rapid excretion from the body. In order to prepare highly concentrated, carrier free 188Re-MAG3, S-benzoyl mercaptoacetyltriglycine (S-Bz-MAG3) was synthesized, labeled with carrier free 188Re. The overall yield of S-Bz-MAG3 is higher than those published in the literature. Dependence of the labeling yield of 188Re-MAG3 upon concentrations of reducing agent, pH, reaction time, etc. was examined and optimum conditions were confirmed. The concentration procedure was succeeded with Sep-Pak C18 cartridge to obtain highly concentrated 188Re-MAG3. In the case of optimun conditions, the labeling yield of 188Re-MAG3 was more than 98%. Radiochemical purity of 188Re-MAG3 was more than 92% after 24 hour storage at room temperature.

关 键 词：放射同位素 ^188RE 放射免疫疗法 

分 类 号：TQ560[化学工程—炸药化工]