Killing effect of Chinese hamster V79 cells exposed to accelerated carbon ions and RBE determination  

作　　者：LI Qiang, ZHOU Guang-Ming, WANG Ju-Fang, LI Wen-Jian, WEI Zeng-Quan(Institute of Modern Physics, the Chinese Academy of Sciences, Lanzhou 730000) 

出　　处：《Nuclear Science and Techniques》2002年第4期259-263,共5页核技术（英文）

基　　金：Jointly supported by the Western Hope Project of the Chinese Academy of Sciences(No. XB010612); the Director Foundation of the Institute of Modern Physics,the Chinese Academy of Sciences (No.ZY010606)

摘　　要：Survival curves of Chinese hamster V79 cells exposed to accclerated carbon ions with linear energy transfers of 125.5, 200 and 700 keV/μm were measured, respectively. Inactivation cross sections corresponding to the irradiation above were deduced from the V79 cell survival curves. They are 7.86±0.17, 10.44±1.11 and 32.32±3.58 μm2 in turn. With the surviving response of V79 cells to 60Co γ-rays as a reference value, relative biological effectiveness at 10%, 20%, 50% and 80% survival levels were given for the accelerated carbon ions. The results showed that carbon ions with LET of 125.5 keV/μm had a higher value of RBE at all the four survival levels than the carbon ions with other LETs. It was prompted that the maximum value of RBE for the V79 cell surviving as the biological endpoint emerged at the LET below 200 keV/μm for carbon ions.Survival curves of Chinese hamster V79 cells exposed to accelerated carbon ions with linear energy transfers of 125.5, 200 and 700keV/μm were measured, respectively. Inactivation cross sections corresponding to the irradiation above were deduced from the V79 cell survival curves. They are 7.86±0.17, 10.44±1.11 and 32.32±3.58μm2 in turn. With the surviving response of V79 cells to 60Co γ-rays as a reference value, relative biological effectiveness at 10%, 20%, 50% and 80% survival levels were given for the accelerated carbon ions. The results showed that carbon ions with LET of 125.5keV/μm had a higher value of RBE at all the four survival levels than the carbon ions with other LETs. It was prompted that the maximum value of RBE for the V79 cell surviving as the biological endpoint emerged at the LET below 200 keV/μm for carbon ions.

关 键 词：放射生物学 碳离子 V79细胞 

分 类 号：Q69[生物学—生物物理学]