抗癌消水膏治疗恶性胸腔积液的疗效与胸水中Th1/Th2细胞因子的相关性  

The Relationship between the Efficacy of Kangai Xiaoshui Cream Treating Malignant Hydrothorax and Th1/Th2 Cytokines in Malignant Hydrothorax

作　　者：贾立群[1] 李佩文[1] 卫广成 万冬桂[1] 蔡光蓉[1] 程志强[1] 

机构地区：[1]中日友好医院,北京100029 [2]山东省烟台市牟平区中医院

出　　处：《中国中医药信息杂志》2002年第12期6-7,共2页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家人事部留学回国人员优秀科研资助项目(1999-122)

摘　　要：目的:探讨抗癌消水膏外治恶性胸水的疗效与胸水中Th1/Th2型细胞因子的关系。方法:在临床上以干扰素腔内注射法为对照组,评价抗癌消水膏的疗效。采用ELISA法检测恶性胸水中IL-2、IL-8、IL-10、IFN-γ水平,比较抗癌消水膏有效组与无效组治疗前后各细胞因子的变化。结果:抗癌消水膏有效组IL-2、IL-8、IFN-γ均有上升,IL-10下降(P<0.05);无效组各细胞因子变化无差异(P>0.05)。结论:恶性胸水中Th1细胞因子优势化是抗癌消水膏治疗恶性胸水的主要机理之一。Objective: To study the relationship between the efficacy of Kangai Xiaoshui Cream treating malignant hydrothorax and Th1 / Th2 cytokines in malignant hydrothorax. Methods:Treated with intrapleural injection of IFN as control group, the malignant hydrothorax patients were treated with external compress of Kangai Xiaoshui Cream and the efficacy of Kangai Xiaoshui Cream were evaluated. Using ELISA, the levels of IL-2, IL-8, IL-10 and IFN-γ in malignant hydrothorax were determined. Of the patients treated with Kangai Xiaoshui Cream, the changes of these cytokines before and after treatment were compared between the responsive cases and the unresponsive cases. Results:In the patients who had response to Kangai Xiaoshui Cream, the levels of IL-2, IL-8, IFN-γwere all increasing after treatment and IL-10 was decreasing (before treatment vs after treatment, P<0.05), while in those who had no response to Kangai Xiaoshui Cream these cytokines had no significant difference before and after treatment (P>0.05). Conclusion: Th1 cytokines superiority in malignant hydrothorax may be one of the main mechanisms of Kangai Xiaoshui Cream for treatment of malignant hydrothorax.

关 键 词：抗癌消水膏 治疗 恶性胸腔积液 疗效 细胞因子 

分 类 号：R259.613[医药卫生—中西医结合] R28[医药卫生—中医内科学]