慢性苯中毒遗传易感性与细胞色素P4502E1基因多态性关系的初步探讨  

Susceptibility to benzene poisoning and genetic polymorphism of cytochrome P4502E1

作　　者：陈艳[1] 吴春玲[1] 戴宇飞[1] 邢彩虹[1] 李桂兰[1] 

机构地区：[1]中国预防医学科学院劳动卫生与职业病研究所,北京100050

出　　处：《卫生研究》2002年第6期414-416,共3页Journal of Hygiene Research

基　　金：国家自然科学基金资助 (No .39870 685)

摘　　要：为探讨细胞色素P45 0 2E1(CYP2E1)基因多态性与苯中毒遗传易感性的关系 ,应用PCR RFLP方法对 35例苯中毒病例、44例苯作业工人及 2 6例正常对照组的细胞色素P45 0 2E1(CYP2E1)基因RsaⅠ和DraⅠ多态进行检测。结果显示 ,CYP2E1基因RsaⅠ位点基因型 (c1 c1、c1 c2和c2 c2 )及等位基因 (c1、c2 )和DraⅠ位点基因型 (DD、CD和CC)及等位基因 (D、C)在三组间的分布频率均无统计学意义。To investigate the relationship between genetic polymorphism of cytochrome P4502E1(CYP2E1)and susceptibility to benzene poisoning. The RsaⅠpolymorphism and DraⅠpolymorphism of CYP2E1 for 35 patients with benzene poisoning and 44 workers exposed to benzene and 26 healthy control were detected by PCR-RFLP. The results showed that the frequencies of genotypes and alletes of RsaⅠand DraⅠ had no significant differences in statistic analysis. It is suggested that the RsaⅠpolymorphism and DraⅠpolymorphism of CYP2E1 and susceptibility to benzene poisoning were indifferences.

关 键 词：慢性苯中毒 遗传易感性 细胞色素 P4502E1 基因多态性 职业卫生 

分 类 号：R135.12[医药卫生—劳动卫生]