特利加压素、垂体后叶素对正常及门脉高压兔门脉血流动力学影响的研究  

Effects of terlipressin and pituitrin on portal hemodynamics in rabbits with prehepatic portal hypertension

作　　者：王天才[1] 张国[1] 梁扩寰[1] 唐望先[1] 但自力[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院肝病研究所,武汉430030

出　　处：《中华消化杂志》2002年第10期595-597,共3页Chinese Journal of Digestion

基　　金：卫生部计财司临床重点学科基金 ( 0 7 95 0 10 2 )

摘　　要：目的　通过比较特利加压素 (terlipressin或glypressin)和垂体后叶素 (pituitrin)对正常及门脉高压兔血流动力学的影响 ,探讨特利加压素治疗门脉高压症的意义。方法　新西兰大白兔 2 0只 ,分为 4组 :①正常兔 +特利加压素组 (4只 ) ;②正常兔 +垂体后叶素组 (4只 ) ;③门脉高压兔 +特利加压素组 (7只 ) ;④门脉高压兔 +垂体后叶素组 (5只 )。部分结扎门静脉主干制备肝前性门脉高压兔模型。在静脉注射特利加压素、垂体后叶素前及注射后 1、5、10、15、2 0、30、6 0min ,观察对门静脉压力 (PVP)、门静脉血流量 (PVF)、心率 (HR)及平均动脉压 (MAP)波动幅度影响。结果　两药的最大降压作用相比 ,差异无显著性 (P >0 .0 5 )。但注射药物后 6 0min ,垂体后叶素的作用基本消失 ,而特利加压素仍有明显的降压作用 (P <0 .0 5 )。而且 ,特利加压素所致门脉高压兔HR、MAP的最大振幅仅为 (6 .5± 0 .5 ) %和(9 .6± 0 .7) % ,低于垂体后叶素的 (2 3.3± 2 .3) %和 (15 .7± 0 .7) % (P <0 .0 5 )。Objective To investigate the significance of terlipressin in treating portal hypertension via comparing the effects of terlipression on the portal hemodynamics, both in normal and portal hypertension rabbits with those of pituitrin. Methods Twenty New Zealand rabbits were randomly divided into four groups as normal rabbits treated with terlipressin ( n =4), normal rabbits treated with pituitrin ( n =4), portal hypertension rabbits treated with terlipressin ( n =7) and portal hypertension rabbits treated with pituitrin ( n =5). Rabbits with portal hypertension were made via partial portal venous ligation. Before and 1, 5, 10, 15, 20, 30, 60 minutes after intravenous administration of terlipressin and pituitrin, the changes of portal vein pressure (PVP), portal vein blood flow (PVF), heart rate (HR) and mean arterial pressure (MVP) were determined respectively. Results There were no significant differences in maximal roles on decreasing PVP between terlipressin and pituitrin ( P >0.05). However, 60 minutes after injection, the roles of pituitrin vanished but terlipressin still had significant effects ( P <0.05). Moreover, there were less changes of HR (6.5±0.5)% and MAP (9.6± 0.7 )% in portal hypertension rabbits with administration of terlipressin than those with pituitrin ( 23.3 ± 2.3 )% and (15.7±0.7)%, respectively ( P <0.05). Conclusions The effects of terlipressin are more persistent, and safe for treating portal hypertension than pituitrin.

关 键 词：特利加压素 垂体后叶素 门静脉高压症 血液动力学 肝硬化 动物实验 

分 类 号：R965[医药卫生—药理学]