穿心莲片生产过程中脱水穿心莲内酯的含量变化  

Changes of Dehydroandrographolide's Contents of Andrographis Tablet in the Process of Production

作　　者：黄晓丹[1] 苏子仁[1] 赖小平[1] 林树海[1] 董晓兵[1] 刘中秋[1] 谢培山 

机构地区：[1]广州中医药大学新药开发中心,广东广州510405 [2]广州市药品检定所,广东广州510160

出　　处：《中国中药杂志》2002年第12期911-913,共3页China Journal of Chinese Materia Medica

基　　金：广东省科技计划项目(A301030203)

摘　　要：目的:了解穿心莲片在生产过程中化学成分的含量变化。方法:采用TLCS,TLC,HPLC法对穿心莲片生产过程中的各阶段产物的有效成分含量进行监测,并观察热对其化学成分的影响。结果:穿心莲片按现有的药典工艺生产,穿心莲内酯损失殆尽,只能检测到脱水穿心莲内酯,引致化学变化的主要因素是工艺过程中的加热。结论:避免热处理或缩短热处理时间是减少有效成分损失的有效因素。Objective: To recognize changes in the contents of ingredients of Andrographis Tablet in the process of production. Method: Adopting TLCS,TLC,HPLC to detect effective contents of ingredients which are produced in every stage of process of Andrographis Table's production. Result: Handling with the fresh Herba Andrographis according to current pharmacopeoia's technology, it showed that only dehyandrographolide can be detected. It indicated that the main factor that leads to chemical change is the heating process in the process of production. Conclusion: Avoiding heating treatment or reducing heating treatment time is the main factor to protect the effective ingredients.

关 键 词：穿心莲 穿心莲内酯 脱水穿心莲内酯 稳定性 中药制剂 

分 类 号：R283.6[医药卫生—中药学]