自然人群中C反应蛋白与冠心病危险因素的关系  

C-reactive protein and risk factors of coronary heart disease in the general population

作　　者：邵也常[1] 刘小清[1] 吴勇[1] 王丁[2] 戴耀宗[2] 饶栩栩[1] 

机构地区：[1]广东省心血管病研究所流行病室,广州市510100 [2]广东省人民医院检验室

出　　处：《岭南心血管病杂志》2002年第4期229-231,共3页South China Journal of Cardiovascular Diseases

基　　金：广东省重点科研基金项目 (编号 980 79)的部分资料

摘　　要：目的　探讨自然人群中C反应蛋白 (CRP)与冠心病危险因素的关系。方法　采用整群抽样的方法抽取自然人群共 1778人 ,进行心血管病危险因素的调查 ,内容包括问卷调查、一般体检、心电图检查、实验检测等。结果　男、女性之间CRP水平无明显差异 (分别为 2 98± 3 95和2 84± 2 93,P >0 0 5 ) ,CRP与高密度脂蛋白负相关 (β =- 1 84 2 ) ,与甘油三酯 (β =0 74 7)、血糖 (β =1 6 6 8)正相关 ,与总胆固醇、尿酸水平无明显相关性。多元逐步回归分析还发现年龄 (β =0 0 6 2 )、心率 (β =0 0 4 2 )、是否心电图异常(β =0 887)也与CRP有关。结论　CRP与多种冠心病危险因素有关 ,可能在冠心病的发生。Objectives To investigate the relationship between C reactive protein (CRP) and some risk factors of coronary heart disease (CHD) in the general population. Methods 1 778 subjects (864 male and 914 female) aged 30 to 60 years who were recruited with cluster sampling were measured CHD risk factors, include questionnaire, conventional physical examination, electrocardiogram and laboratory test et al. Results The CRP concentrations are not difference in sex (2.98 mg/L±3.95 mg/L in male and 2.84 mg/L ±2 93 mg/L in female, P >0 05). CRP value positively associated with triglycerides (β=0 747), glucose (β=1.668) and inversely correlated with high density lipoprotein cholesterol (β= -1.842 ), but not significantly associated with total cholesterol, uric acid. CRP concentrations also associated with age ( β=0.062 ), heartbeat (β=0.042), normal electrocardiogram or not (β=0.887) by stepwise regression analysis. Conclusions The results suggest CRP values may contribute to the increased CHD risk.

关 键 词：自然人群 C反应蛋白 冠心病 危险因素 

分 类 号：R541.4[医药卫生—心血管疾病]