清醒大鼠动脉压力感受性反射对血压的控制  

Arterial Baroreflex-Blood Pressure Control in Conscious Rats

作　　者：孔宪波[1] 程勇[1] 陈力 苏定冯 

机构地区：[1]第二军医大学训练部药理学教研室,200433

出　　处：《第二军医大学学报》1992年第3期238-240,共3页Academic Journal of Second Military Medical University

基　　金：国家自然科学基金(2880743)

摘　　要：作者报道了一种新方法用于测定清醒大鼠动脉压力感受性反射对血压的控制(ABR-BP)。该法用比较阻断反射的传出通路前后机体对血管紧素Ⅱ升压反应面积的差异来定量ABR-BP。结果发现,血压波动性与ABR-BP呈非常显著的负相关,而与ABR对心率的控制无关。自发性高血压大鼠(SHR)和肾血管性高血压大鼠(RVHR)的ABR-BP明显低于WKY大鼠。SHR的ABR-BP降低主要是迷走神经成分受损。A new method to measure arterial baroreflex-blood pressure control (ABR-BP) in conscious rats was established in our laboratory. ABR-BP was quantitatively determined by comparing the pressor responses to All before and after the blockade of the efferent pathway of baroreflex. It was found that there was a close relationship between Hood pressure variability and ABR-BP rather than arterial baroreflex-heart period control. ABR-BP was significantly lower in SHR and RVHR than in WKY rats. The lower ABR-BP in SHR was due mainly to the impairment of parasympathetic component

关 键 词：高血压 动脉压力 感受性反射 

分 类 号：R544.1[医药卫生—心血管疾病]