葡萄籽提取物对小鼠动脉粥样硬化的作用  

THE ANTIATHEROSCLEROTIC EFFECT OF THE EXTRACT FROM GRAPE SEED IN C57BL/6J MICE

作　　者：徐贵发[1] 于红霞[1] 王淑娥[1] 郝风荣[1] 刘清君[1] 

机构地区：[1]山东大学公共卫生学院,济南250012

出　　处：《营养学报》2002年第4期377-379,共3页Acta Nutrimenta Sinica

基　　金：山东省科委资助 ( No.1999BB1CA4)

摘　　要：目的 :　探讨葡萄籽乙醇提取物对已形成的小鼠动脉粥样硬化 (AS)病变的消退作用。方法 :　采用 AS敏感株近交系 C5 7BL/6 J小鼠 ,经致 AS饲料饲喂 2 0 w复制 AS模型 ,然后改用普通饲料 ,同时给予葡萄籽提取物灌胃干预 4w,于 2 5 w末 ,眼球放血处死小鼠 ,并取主动脉作病理切片 ,观察血脂及形态学变化。结果 :　经致 AS饲料饲喂 2 0 w的小鼠 ,主动脉部位已形成了含有大量泡沫细胞的早期 AS病变 ,主动脉损伤评分为 7.4± 1 .3 ,且血清甘油三酯、胆固醇和丙二醛含量大幅度升高。经给予葡萄籽提取物灌胃 ,小鼠主动脉损伤较模型组明显减轻 ,主动脉损伤评分为 6 .4± 1 .2 ,血清甘油三酯、胆固醇和丙二醛含量均明显下降 ,高剂量组效果为佳。结论 :　葡萄籽提取物具有减轻已形成的动脉粥样硬化早期病变的作用 ,且能使血清甘油三酯、胆固醇和丙二醛含量下降 。Objective: To investigate the antiatherosclerotic effect of the extract from grape seed in C57BL/6J mice. Method: The mice were fed with atherosclerotic diet for 20 w and then with basic diet or different dosage of grape seed extract for 4 w. The blood samples were examined for blood lipid. The sections of aorta were examined and scored microscopically. Results: After fed with atherogenic diet for 20 w, the aortic score was 7.2±1.3 and TG, Chol and MDA in serum were significantly increased. After fed with the extract of grape seed for 4 w, the aortic score was reduced to 6.0±1.2, and TG, TC, and MDA levels also decreased. Conclusion: The extract of grape seed has antiatherosclerotic effect.

关 键 词：葡萄籽提取物 动脉粥样硬化 主动脉损伤评分 血脂 

分 类 号：R285.5[医药卫生—中药学]