肺心病人红细胞2,3-二磷酸甘油酸和氧亲和力研究  

Oxygen affinity and 2, 3-diphosphoglycerate level of erythro-cytes in patients with cor pulmonale

作　　者：李松柏[1] 钱桂生[1] 毛宝龄[1] 

机构地区：[1]第三军医大学新桥医院呼吸中心,630037

出　　处：《第三军医大学学报》1992年第5期419-422,共4页Journal of Third Military Medical University

摘　　要：本文对肺心病54例和对照组23例的动脉血气、红细胞内pH(pHi)、2,3-二磷酸甘油酸(2,3-DPG)、标准P_(50)(P_(50(std)))和体内P_(50)(P_(50(iv)))进行了研究。结果表明,肺心病人pHi无明显变化,但红细胞内外pH差降低;肺心病Ⅱ型呼吸衰竭人P_(50(std))降低(P<0.05),而P_(50(iv))无明显变化。提示:肺心病人P_(50(std))不能准确反映P_(50(iv))变化;P_(50(iv))相对稳定、与“最佳P_(50)”相吻合,是机体对慢性缺氧的一种适应;Arterial blood gases,intraerythrocytic pH(pHi),2,3-diphosphoglycerate,standard P50(P50(aid))and in vivo P50(P50iv)were determined in 54 patients with cor pulmonale and in 23 normal subjects.It was found that there was no significant change of pHi but the difference between pHi and extraerythrocytic pH was decreased.P50aid was decreased(P<0.05)while P50iv,remained essentially unchanged in those patients showing type I respiratory failure.These findings suggest the following:P50aid a cannot accurately reflect the changes of P50iv P50aid is relatively stable and coincides with the 'optimal P50' P50iv indicates the beneficial adaptation of the body to chronic hypoxia.Relative intraerythrocytic alkalosis plays an important role to release the excessive right shifting of the oxyhemoglobin dissociation curve resulting from hypercapnia in patients with cor pulmonale.

关 键 词：肺心病 二磷酸甘油酸 氧亲和力 

分 类 号：R541.5[医药卫生—心血管疾病]