单纯性肥胖成人神经内分泌功能与心理健康状况关系的追踪研究  

A 1-year follow-up investigation of the neuroendocrine function and psychological status for simple obesity adults

作　　者：姚树桥[1] 李红政[1] 蔡太生[1] 朱熊兆[1] 王丽[1] 

机构地区：[1]中南大学湘雅二院,湖南长沙410011

出　　处：《中国行为医学科学》2002年第6期625-627,共3页Chinese Journal of Behavioral Medical Science

基　　金：国家自然科学基金资助项目 ( 394 30 0 70 )

摘　　要：目的　研究单纯性肥胖成人神经内分泌功能与心理健康状况的关系及其变化特点。方法　对 82例超重肥胖者和 73名适宜体重者进行了为期一年的前瞻性对照追踪 ,采用症状自评量表 (SCL 90 )评定心理健康状况 ,放射免疫法测定肾上腺皮质激素(ACTH)、皮质醇 (COR)、胰高血糖素 (GLU)和胰岛素。用胰岛素抵抗 (IR)、胰岛素敏感指数 (IAI)、Homeβ细胞功能指数 (HBCI)评定胰岛素敏感性和胰岛 β细胞内分泌功能。结果　超重肥胖组ACTH、GLU、HBCI、IR明显高于适宜体重组 ,也存在较多的心理症状 ,其IR、IAI与精神病性症状均有关。但追踪期间超重肥胖组心理状态有明显改善。结论　单纯性肥胖成人的神经内分泌功能与心理状态可能有关。Objective To explore the characteristic of neuroendocrine function and psychological status among simple obesity adults during 1 year follow up period. Methods Symptom Checklist 90(SCL-90) was used for the prospective control study to investigate the psychological status and its relation to neuroendocrine function between 82 overweight obesity adults and 73 proper weight adults. ACTH?COR?glucagon(GLU)and insulin were tested by radioimmunoassay. βcell endocine function of pancreas and insulin sensitivity were assessed by insulin action index(IAI)?insulin resistance(IR)and Homa beta cell function index(HBCI). Results ACTH?GLU?HBCI and IR level of overweight obesity group(OOG) were higher than that of proper weight group(PWG). OOG had more and obviously poor psychological status before the study, and had an obvious improvement in the follow up period. there had positive relation between IR?IAI and psychotic score in OOG. Conclusion There has difference in the psychological status and neuroendocrine function between OOG and PWG. neuroendocrine function has positive relation to psychological status in OOG.

关 键 词：单纯性肥胖 成人 神经内分泌功能 心理健康状况 追踪研究 

分 类 号：R395.1[哲学宗教—心理学]