肺泡蛋白沉积症的细胞超微结构的观察  

The ultrastructrual observation of pulmonary alveolar proteinosis

作　　者：陈明霞[1] 杨少毅[1] 

机构地区：[1]西安交通大学医学院电镜室,陕西西安710061

出　　处：《电子显微学报》2002年第6期856-858,共3页Journal of Chinese Electron Microscopy Society

摘　　要：目的 :通过对临床少见的肺泡蛋白沉积症 (PAP)的电镜观察 ,探讨其超微结构特点。方法 :选择 5例疑为PAP的病人 ,经纤维支气管镜活检取出肺组织 ,制备超薄切片后进行电镜观察。结果 :细胞超微结构的改变为Ⅱ型肺泡上皮细胞增生 ,在肺泡腔内充满细胞碎片、细颗粒状结构、嗜锇板层体及大量泡沫样外观的肺泡巨噬细胞。The pulmonary alveolar proteinosis (PAP) is a kind of causally unknown and infrequent pulmonary diseases. The pathologic feature is that the phospholipoprotein like surfactant, positive while dyed with periodic acid schiff has excessively accumulated in the alveoli cavity and the terminus of the bronchus. In this article, we selected five patients who have probably caught PAP. Vitally examed with the micro bronchoscope,their pulmonary tissue were taken,the ultra thin sections were observed by TEM. Two of these five patients could be excluded from catching PAP and the cellular ultrastructural alteration of the rest was fundamentally the same and corresponded with the pathologic alteration of the pulmonary tissue of PAP. The cellular ultrastructural feature of PAP is that of the typeⅡovergrown of alveolar epithelial cell and the abundence of that cellular chips, pulmonary surfactant, protein like structures and a number of spumous alveolar macrophages in the alveoli cavity and the terminus of the bronchus. The aboundance of these substances lead to the depression of the alveolar function and render the patients dyspnoea. The alteration of these ultrastructures sometimes is difficult to find with the LM. The use of the EM can help greatly in the clinical diagnosis.

关 键 词：肺泡蛋白沉积症 透射电镜 超微结构 病理细胞学 PAP 肺组织 临床诊断 

分 类 号：R563.9[医药卫生—呼吸系统]